Cardiac MR (CMR) is a standard modality for assessing ventricular function of single ventricles. CMR feature-tracking (CMR-FT) is a novel application enabling strain measurement on cine MR images and is used in patients with congenital heart diseases. We sought to assess the feasibility of CMR-FT in Fontan patients and analyze the correlation between CMR-FT strain values and conventional CMR volumetric parameters, clinical findings, and biomarkers. Global circumferential (GCS) and longitudinal (GLS) strain were retrospectively measured by CMR-FT on Steady-State Free Precession cine images. Data regarding post-operative course at Fontan operation, and medication, exercise capacity, invasive hemodynamics, and blood biomarkers at a time interval ± 6 months from CMR were collected. Forty-seven patients underwent CMR 11 ± 6 years after the Fontan operation; age at CMR was 15 ± 7 years. End-diastolic volume (EDV) of the SV was 93 ± 37 ml/m², end-systolic volume (ESV) was 46 ± 23 ml/m², and ejection fraction (EF) was 51 ± 11%. Twenty (42%) patients had a single right ventricle (SRV). In single left ventricle (SLV), GCS was higher (p < 0.001), but GLS was lower (p = 0.04) than in SRV. GCS correlated positively with EDV (p = 0.005), ESV (p < 0.001), and EF (p ≤ 0.0001). GLS correlated positively with EF (p = 0.002), but not with ventricular volumes. Impaired GCS correlated with decreased ventricular function (p = 0.03) and atrioventricular valve regurgitation (p = 0.04) at echocardiography, direct atriopulmonary connection (p = 0.02), post-operative complications (p = 0.05), and presence of a rudimentary ventricle (p = 0.01). A reduced GCS was associated with increased NT-pro-BNP (p = 0.05). Myocardial deformation can be measured by CMR-FT in Fontan patients. SLVs have higher GCS, but lower GLS than SRVs. GCS correlates with ventricular volumes and EF, whereas GLS correlates with EF only. Myocardial deformation shows a relationship with several clinical parameters and NT-pro-BNP.

心脏 MR (CMR) 是评估单心室心室功能的标准模式。CMR 特征跟踪 (CMR-FT) 是一种新颖的应用程序，可以对电影 MR 图像进行应变测量，并用于先天性心脏病患者。我们试图评估 CMR-FT 在 Fontan 患者中的可行性，并分析 CMR-FT 应变值与常规 CMR 体积参数、临床发现和生物标志物之间的相关性。全局圆周 (GCS) 和纵向 (GLS) 应变通过 CMR-FT 在稳态自由进动电影图像上进行回顾性测量。收集有关 Fontan 手术的术后过程、药物、运动能力、侵入性血流动力学和血液生物标志物的数据，时间间隔为 CMR ± 6 个月。47 名患者在 Fontan 手术后 11 ± 6 年接受了 CMR；CMR 的年龄为 15 ± 7 岁。SV 的舒张末期容积 (EDV) 为 93 ± 37 ml/m^如图2所示，收缩末期容积 (ESV) 为 46 ± 23 ml/m ²，射血分数 (EF) 为 51 ± 11%。20 (42%) 名患者有单个右心室 (SRV)。在单左心室 (SLV) 中，GCS 高于 ( p  < 0.001)，但 GLS 低于 ( p  = 0.04) 在 SRV。GCS 与 EDV ( p  = 0.005)、ESV ( p  < 0.001) 和 EF ( p  ≤ 0.0001) 呈正相关。GLS 与 EF 呈正相关（p  = 0.002），但与心室容积无关。GCS 受损与心室功能下降 ( p  = 0.03) 和房室瓣关闭不全 ( p  = 0.04) 在超声心动图、直接房肺连接 (p  = 0.02)、术后并发症 ( p  = 0.05) 和存在发育不全的心室 ( p  = 0.01)。GCS 减少与 NT-pro-BNP 增加相关（p  = 0.05）。可以通过 CMR-FT 在 Fontan 患者中测量心肌变形。SLV 的 GCS 较高，但 GLS 比 SRV 低。GCS 与心室容积和 EF 相关，而 GLS 仅与 EF 相关。心肌变形显示出与几个临床参数和 NT-pro-BNP 的关系。