Aldosterone overproduction and lipid metabolic disturbances between idiopathic hyperaldosteronism (IHA) and unilateral aldosterone-producing adenoma (APA) have been inconsistently linked in patients with primary aldosteronism. Moreover, KCNJ5 mutations are prevalent among APAs and enhance aldosterone synthesis in adrenal cortex. We aimed to investigate the prevalence of metabolic syndrome (MetS) in each primary aldosteronism subtype and observe the role of KCNJ5 mutations among APAs on the distribution of abdominal adipose tissues quantified using computed tomography (CT), including their changes postadrenalectomy.

中文翻译：

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产生醛固酮的腺瘤携带 KCNJ5 突变与代谢紊乱和腹部肥胖的患病率较低有关。

在原发性醛固酮增多症患者中，特发性醛固酮增多症 (IHA) 和单侧醛固酮分泌腺瘤 (APA) 之间的醛固酮过度生成和脂质代谢紊乱之间的联系不一致。此外，KCNJ5 突变在 APA 中普遍存在，并增强肾上腺皮质中的醛固酮合成。我们的目的是调查代谢综合征 (MetS) 在每个原发性醛固酮增多症亚型中的患病率，并观察 APA 中 KCNJ5 突变对使用计算机断层扫描 (CT) 量化的腹部脂肪组织分布的作用，包括肾上腺切除术后的变化。