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Influence of Insulin Application Time and High-Intensity Intermittent Exercise on Hypoglycemic Risk in Adolescents With Type 1 Diabetes
Pediatric Exercise Science ( IF 1.8 ) Pub Date : 2021-11-23 , DOI: 10.1123/pes.2020-0150
Valderi de Abreu de Lima 1 , Gabriel Ribeiro Cordeiro 2 , Luis Paulo Gomes Mascarenhas 2 , Suzana Nesi França 1 , Juliana Pereira Decimo 1 , Andréia Araújo Porchat de Leão 1 , Camila Kapp Fritz 1 , Neiva Leite 1
Affiliation  

Purpose: The study analyzed the influence of exercise on hypoglycemia episodes postexercise and in the subsequent 24 hours in children and adolescents with type 1 diabetes. Methods: Thirty young people performed the same protocol of physical exercises for 1 hour (Ex1h) and 2 hours (Ex2h) after the administration of insulin. They performed 30 minutes of exercise on a cycle ergometer with a load of 60% of maximal oxygen uptake, interspersed with maximum intensity sprints lasting 10 seconds every 5 minutes. Results: Regarding the occurrence of hypoglycemia, in the 8 hours following the exercises, there was no occurrence in Ex1h (χ2 = 0.001; P = .0001) and a greater proportion for Ex2h (n = 71 episodes, 53.8%), while Ex1h had a higher number of nocturnal hypoglycemic episodes (n = 60, 71.4%) compared with Ex2h (n = 31, 23.1%, χ2 = 49.521, P = .0001), Ex1h triggered a lower number of hypoglycemia (n = 84) than Ex2h (n = 134, χ2 = 11.504, P = .001). There was a greater reduction in the average amount of fast-acting insulin administered the day after Ex1h compared with Ex2h (P = .031). Conclusions: Intermittent exercise performed 1 hour after insulin administration shows a lower risk of hypoglycemia within 8 hours after exercise, as well as a reduction in insulin the following day.



中文翻译:

胰岛素应用时间和高强度间歇性运动对青少年 1 型糖尿病患者低血糖风险的影响

目的该研究分析了运动对 1 型糖尿病儿童和青少年运动后和随后 24 小时内低血糖发作的影响。方法: 30 名年轻人在注射胰岛素后 1 小时 (Ex1h) 和 2 小时 (Ex2h) 进行了相同的体育锻炼方案。他们在自行车测力计上进行了 30 分钟的运动,负荷为最大摄氧量的 60%,穿插着每 5 分钟持续 10 秒的最大强度冲刺。结果关于低血糖的发生,运动后8小时内,Ex1h未发生( χ2 =  0.001; P = .0001),Ex2h 的比例更大(n = 71 次,53.8%),而 Ex1h 的夜间低血糖发作次数(n = 60, 71.4%)高于 Ex2h(n = 31, 23.1%, χ 2  = 49.521, P  = .0001),Ex1h 引发的低血糖症 (n = 84) 低于 Ex2h (n = 134, χ 2  = 11.504, P  = .001)。与 Ex2h 相比,Ex1h 后一天的速效胰岛素平均用量减少幅度更大(P  = .031)。结论胰岛素给药后 1 小时进行的间歇性运动显示,运动后 8 小时内发生低血糖的风险较低,并且第二天的胰岛素水平降低。

更新日期:2022-01-21
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