Laryngopharyngeal reflux (LPR) has been suggested as a possible cause of post-thyroidectomy syndrome. However, the pathophysiology and relationship between thyroidectomy and LPR have not been well investigated. We aimed to evaluate the correlation between thyroidectomy and LPR by assessing changes in LPR-related symptoms and laryngoscopic findings before and after thyroidectomy. Ninety-five patients who underwent thyroidectomy with or without central neck dissection were included. The reflux finding score (RFS) and reflux symptom index (RSI) were investigated one day before surgery and two, four, six, and twelve months after surgery. The RFS scores increased significantly after thyroidectomy and decreased to the preoperative level 12 months after surgery. The RSI scores increased after surgery and decreased gradually by 12 months postoperatively, although it was not statistically significant. The RSI and RFS scores improved with the administration of proton pump inhibitors. In conclusion, LPR-related laryngoscopic findings were exacerbated after uncomplicated thyroidectomy. Further studies using pH-monitoring and esophageal manometry are required to investigate the possible deterioration of LPR itself and the UES pressure after thyroidectomy.

中文翻译：

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甲状腺切除术后反流发现评分 (RFS) 加重。

喉咽反流 (LPR) 被认为是甲状腺切除术后综合征的可能原因。然而，甲状腺切除术与 LPR 之间的病理生理学和关系尚未得到很好的研究。我们旨在通过评估甲状腺切除术前后 LPR 相关症状和喉镜检查结果的变化来评估甲状腺切除术与 LPR 之间的相关性。纳入了 95 名接受甲状腺切除术伴或不伴颈中央清扫术的患者。在手术前 1 天和手术后 2、4、6 和 12 个月调查反流发现评分 (RFS) 和反流症状指数 (RSI)。甲状腺切除术后RFS评分显着升高，术后12个月降至术前水平。术后 RSI 评分升高，术后 12 个月逐渐下降，虽然没有统计学意义。RSI 和 RFS 评分随着质子泵抑制剂的给药而改善。总之，在无并发症的甲状腺切除术后，LPR 相关的喉镜检查结果恶化。需要使用 pH 监测和食管测压法进行进一步研究，以调查甲状腺切除术后 LPR 本身和 UES 压力的可能恶化。