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2-HG modulates glioma macrophages via Trp metabolism
Nature Cancer ( IF 22.7 ) Pub Date : 2021-07-26 , DOI: 10.1038/s43018-021-00231-7
Marie Jo Halaby 1 , Tracy L McGaha 1, 2
Affiliation  

Immuno-oncology approaches have shown little efficacy against high-grade glioma, a devastating manifestation of brain cancer. A new study now finds a metabolic vulnerability in IDH1-mutant glioma that can be targeted to reprogram tumor-infiltrating macrophages and create a tumor microenvironment that is more responsive to immune-checkpoint therapy.

中文翻译:

2-HG 通过色氨酸代谢调节胶质瘤巨噬细胞

免疫肿瘤学方法对高级别胶质瘤(脑癌的破坏性表现)几乎没有效果。一项新的研究现在发现了 IDH1 突变型胶质瘤的代谢脆弱性,可以靶向重编程肿瘤浸润性巨噬细胞并创建对免疫检查点治疗更敏感的肿瘤微环境。
更新日期:2021-07-27
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