Probiotics immunomodulatory properties and their beneficial effects for diseases such as multiple sclerosis (MS) are reported by several studies. The current systematic review and meta-analysis aimed to investigate the favourable effects of probiotics in improving experimental autoimmune/allergic encephalomyelitis (EAE) as an animal model of MS. We systematically searched Scopus, Web of Sciences (ISI), and PubMed databases to identify relevant studies from the inception of these databases to December 2019. A total of 15 animal studies met the inclusion criteria, while no human study met the inclusion criteria. The association between consumption of probiotics and each sign was calculated using the producing pooled odd ratios (95% confidence interval [95% CI]) in a random effect model. The meta-analysis revealed the significant effect of probiotics on the incidence of EAE, weight gain, and clinical symptoms. However, the effects of probiotics on the duration of the disease varied by probiotic strain. The administration of probiotics was associated with a significant reduction in the risk of mortality only in female animals. Moreover, the meta-analysis revealed the promising effects of probiotics on the prevention and management of EAE.

中文翻译：

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益生菌在实验性自身免疫性脑脊髓炎（MS 动物模型）中的疗效：系统评价和荟萃分析

多项研究报告了益生菌的免疫调节特性及其对多发性硬化症 (MS) 等疾病的有益作用。当前的系统评价和荟萃分析旨在研究益生菌作为 MS 动物模型在改善实验性自身免疫性/过敏性脑脊髓炎 (EAE) 方面的有利作用。我们系统地检索了 Scopus、Web of Sciences (ISI) 和 PubMed 数据库，以识别从这些数据库成立到 2019 年 12 月的相关研究。共有 15 项动物研究符合纳入标准，而没有人类研究符合纳入标准。使用随机效应模型中产生的汇总比值比（95% 置信区间 [95% CI]）计算益生菌消耗量与每个体征之间的关联。荟萃分析揭示了益生菌对 EAE 发生率、体重增加和临床症状的显着影响。然而，益生菌对疾病持续时间的影响因益生菌菌株而异。仅在雌性动物中，益生菌的施用与死亡风险的显着降低相关。此外，荟萃分析揭示了益生菌对 EAE 预防和管理的有希望的作用。