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Use of Pistacia lentiscus mastic for sustained-release system of chlorocresol and benzoic acid for in vitro prevention of bacterial colonization of silicon urinary catheter
Letters in Applied Microbiology ( IF 2.4 ) Pub Date : 2021-07-26 , DOI: 10.1111/lam.13541
R M Goda 1 , M M Shohayeb 1
Affiliation  

Urinary tract infections (UTI) are among the most common types of nosocomial infections. Patients with indwelling urinary catheters are at the highest risk of getting infections. A sustained-release method of chlorocresol and benzoic acid using a varnish of Pistacia lentiscus mastic was developed to prevent catheter colonization by Staphylococcus epidermidis, Staphylococcus aureusEscherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa. Coatings of both antiseptics significantly reduced the number of colonizing bacteria on silicon urinary catheters for 72 h. Chlorocresol-coated catheters were significantly (P ≤ 0·05) more effective than benzoic acid. Except for the Pr. mirabilis, chlorocresol completely inhibited the colonization of catheters by the tested bacteria for 48 h. Nonetheless, the colonization of catheters by Pr. mirabilis was significantly reduced after 48 and 72 h by more than 3·5 logs. Although benzoic acid failed to completely inhibit bacterial growth, it significantly reduced the colonization of the catheters by all the tested bacteria by more than two logs for 72 h. The inhibition of colonization of catheters was confirmed by examining the tested catheters by scanning electron microscopy. The obtained results indicate the potential benefits of using mastic as a varnish for sustaining the release of chlorocresol and benzoic acid to prevent and reduce the colonization of urinary catheters by bacteria.

中文翻译:

Pistacia lentiscus 乳香在氯甲酚和苯甲酸缓释系统中用于体外预防硅导尿管细菌定植的用途

尿路感染 (UTI) 是最常见的医院感染类型之一。留置导尿管的患者感染风险最高。开发了一种使用Pistacia lentiscus乳香清漆的氯甲酚和苯甲酸的缓释方法,  以防止导管被 表皮葡萄球菌、金黄色葡萄球菌、 大肠杆菌、肺炎克雷伯菌、奇异变形杆菌铜绿假单胞菌定植。两种防腐剂的涂层在 72 小时内显着减少了硅导尿管上的定植细菌数量。氯甲酚涂层导管 比苯甲酸显着(P≤0·05)更有效除了公关。奇异果、氯甲酚在48小时内完全抑制了受试细菌对导管的定植。尽管如此, Pr对导管的定植 。48 小时和 72 小时后,奇异果 显着减少了 3·5 对数以上。尽管苯甲酸未能完全抑制细菌生长,但它在 72 小时内显着减少了所有测试细菌对导管的定植量超过两个对数。通过扫描电子显微镜检查测试的导管来确认导管定植的抑制。获得的结果表明,使用乳香作为清漆持续释放氯甲酚和苯甲酸以防止和减少细菌在导尿管中定植的潜在益处。
更新日期:2021-07-26
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