Abstract

In this study, two new Co(II)-containing coordination polymers (CPs) with the chemical formulae of {[Co(tib)(betc)_0.5]·H₂O}_n (1, tib = 1,3,5-tris(1-imidazolyl)benzene, betc⁴⁻ = 1,2,4,5-benzenetetracarboxylate) and {[Co(tib)(H₂O)]·(1,5-nds)}_n (2, 1,5-nds²⁻ = 1,5-naphthalenedisulfonate) have been successfully prepared by reaction of Co(II) salt with the tib ligand using different carboxylic acid co-ligands. Furthermore, the application values of compounds 1 and 2 on breast cancer combined with psychological counseling was evaluated. The Cell Counting Kit-8 (CCK-8) was conducted to evaluate the inhibitory activity of the compound on the breast cancer cell viability was determined. In addition to this, the activation levels of the vascular endothelial growth factor (VEGF) signaling pathway was also determined with real time reverse transcription-polymerase chain reaction (RT-PCR).

摘要

在这项研究中，两种新的含 Co(II) 的配位聚合物 (CPs) 的化学式为 {[Co(tib)(betc) _0.5 ]·H ₂ O} _n ( 1 , tib = 1,3,5-三(1-咪唑基)苯，betc ^4- = 1,2,4,5-苯四^羧酸酯)和{[Co(tib)(H ₂ O)]·(1,5-nds)} _n ( 2 , 1, 5-nds ²⁻ = 1,5-萘二磺酸盐）已通过使用不同的羧酸共配体使 Co(II) 盐与 tib 配体反应成功制备。此外，化合物1和2的应用价值对乳腺癌结合心理咨询进行了评价。进行细胞计数试剂盒-8 (CCK-8) 以评估化合物对确定的乳腺癌细胞活力的抑制活性。除此之外，血管内皮生长因子 (VEGF) 信号通路的激活水平也通过实时逆转录聚合酶链反应 (RT-PCR) 确定。