Invariant natural killer T cells (iNKTs) bridge the innate immunity with the adaptive immunity and their interaction with B cells has been extensively studied. Here, we give a complete overview of these two cells, from their mechanism of interaction to clinical prospects and existing problems. In our introduction, we describe the relationship between iNKTs and B cells and explore the current research hotspots and future directions. We begin with how B cells interact and benefit from the innate and adaptive help of iNKTs. Next, we describe the multiple roles of these cells in infections, autoimmunity, and cancers. Lastly, we look into the potential immunotherapies that can be based on iNKTs and the possible treatments for infectious, autoimmune, and other diseases.

中文翻译：

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iNKT细胞与B细胞的相互作用

不变的自然杀伤 T 细胞 (iNKT) 将先天免疫与适应性免疫联系起来，并且已经广泛研究了它们与 B 细胞的相互作用。在这里，我们对这两种细胞进行了完整的概述，从它们的相互作用机制到临床前景和存在的问题。在我们的介绍中，我们描述了 iNKTs 和 B 细胞之间的关系，并探讨了当前的研究热点和未来的方向。我们从 B 细胞如何相互作用和受益于 iNKT 的先天和适应性帮助开始。接下来，我们描述了这些细胞在感染、自身免疫和癌症中的多重作用。最后，我们研究了基于 iNKT 的潜在免疫疗法以及针对传染性、自身免疫性和其他疾病的可能疗法。