We present herein a label-free method based on surface-enhanced Raman spectroscopy (SERS) that was performed using a silicon-based SERS platform. The differentiation between primary and secondary brain tumors SERS data was completed partial least squares (PLS) method with a very high 85% of accuracy (in only first and second factors), whereas calculated using principal component analysis (PCA) method gives 74% (in two consecutive components). Additionally, due to the fact that the interleukin-10 (IL-10) cytokine receptor may act in cancer as both an immunosuppressive and an immunostimulant factor, the correlation between the tumor grading and the cytokine receptor are presented. Obtained data indicate that the function of IL-10 cytokine receptor subunit alpha most probably depends or is closely related to the tumor stage.

中文翻译：

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基于表面增强拉曼光谱和多变量分析的分级脑肿瘤与白细胞介素10受体亚基α之间的关联

我们在此提出了一种基于表面增强拉曼光谱 (SERS) 的无标记方法，该方法使用基于硅的 SERS 平台进行。原发性和继发性脑肿瘤 SERS 数据之间的区分是通过偏最小二乘 (PLS) 方法完成的，具有非常高的 85% 准确度（仅在第一和第二因素中），而使用主成分分析 (PCA) 方法计算得出 74%（在两个连续的组件中）。此外，由于白细胞介素 10 (IL-10) 细胞因子受体可能在癌症中作为免疫抑制和免疫刺激因子起作用，因此呈现了肿瘤分级和细胞因子受体之间的相关性。获得的数据表明，IL-10 细胞因子受体亚基 α 的功能很可能取决于肿瘤分期或与肿瘤分期密切相关。