Abstract

Research on the synthesis of heterocyclic scaffolds is an important challenge in organic synthesis because heterocycles are an important block in the structure of many drugs and pharmaceutical molecules. Ynamides are one the most versatile and enabling building blocks in organic synthesis because they have recently used starting materials for the construction of multifunctional compounds especially heterocyclic compounds. In recent times, a number of catalytic systems have been reported in the literature for the synthesis of heterocyclic scaffolds from ynamide derivatives. This review has outlined the extensive application of ynamide derivatives in the synthesis of a library of heterocyclic scaffolds.

摘要

杂环支架的合成研究是有机合成中的一个重要挑战，因为杂环是许多药物和药物分子结构中的重要模块。酰胺类化合物是有机合成中用途最广、功能最强大的构建模块之一，因为它们最近已将起始材料用于构建多功能化合物，尤其是杂环化合物。最近，文献中报道了许多催化系统，用于从 ynamide 衍生物合成杂环支架。本综述概述了 ynamide 衍生物在杂环支架库合成中的广泛应用。