Background: New effective, economical and safe antimalarial drugs are urgently needed due to the development of multi-drug-resistant strains of the parasite. Homeopathy uses ultra-diluted doses of various substances to stimulate autoregulatory and self-healing processes to cure various ailments. The aim of the study was to evaluate the in vitro and in vivo antimalarial efficacy of a homeopathic drug, Chininum sulphuricum 30C. Methods: In vitro antiplasmodial activity was screened against the P. falciparum chloroquine-sensitive (3D7) strain, and cell viability was assessed against normal human dermal fibroblasts and HepG2 cells. Suppressive, preventive and curative studies were carried out against P. berghei-infected mice in vivo. Results: Chininum sulphuricum (30C) revealed good antiplasmodial activity in vitro, with 92.79 ± 6.93% inhibition against the 3D7 strain. The cell viability was 83.6 ± 0.6% against normal human dermal fibroblasts and 95.22 ± 5.1% against HepG2 cells. It also exhibited suppressive efficacy with 95.56% chemosuppression on day 7 with no mortality throughout the follow-up period of 28 days. It also showed preventive activity against the disease. Drug treatment was also safe to the liver and kidney function of the host as evidenced by biochemical studies. Conclusion: Chininum sulphuricum 30C exhibited considerable antimalarial activity along with safety to the liver and kidney function of the host.
Complement Med Res

中文翻译：

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Chiinum Sulphuricum 30C 对疟疾的疗效：体外和体内研究

背景：随着疟原虫多重耐药菌株的发展，迫切需要新的有效、经济、安全的抗疟药物。顺势疗法使用超稀释剂量的各种物质来刺激自动调节和自我修复过程，从而治愈各种疾病。该研究的目的是评估顺势疗法药物 Chininum sulphuricum 30C 的体外和体内抗疟功效。方法：针对恶性疟原虫氯喹敏感 (3D7) 菌株筛选体外抗疟原虫活性，并针对正常人真皮成纤维细胞和 HepG2 细胞评估细胞活力。在体内对感染伯氏疟原虫的小鼠进行了抑制、预防和治疗研究结果： Chininum sulphuricum (30C) 在体外显示出良好的抗疟原虫活性，对 3D7 菌株的抑制率为 92.79 ± 6.93%。细胞活力对正常人真皮成纤维细胞为 83.6 ± 0.6%，对 HepG2 细胞为 95.22 ± 5.1%。它还表现出抑制功效，在第 7 天化疗抑制率为 95.56%，在 28 天的随访期间没有死亡。它还显示出对这种疾病的预防活性。生化研究证明，药物治疗对宿主的肝肾功能也是安全的。结论：硫磺30C具有显着的抗疟活性，对宿主的肝肾功能安全。
补充医学资源