YTH domain containing 2 (YTHDC2) is the largest N6-Methyladenosine (m⁶A) binding protein of the YTH protein family and the only member containing ATP-dependent RNA helicase activity. For further analysing its biological role in epigenetic modification, we comprehensively explored YTHDC2 from gene expression, genetic alteration, protein-protein interaction (PPI) network, immune infiltration, diagnostic value and prognostic value in pan-cancer, using a series of databases and bioinformatic tools. We found that YTHDC2 with Missense mutation could cause a different prognosis in uterine corpus endometrial carcinoma (UCEC), and its different methylation level could lead to a totally various prognosis in adrenocortical carcinoma (ACC), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), lung squamous cell carcinoma (LUSC) and UCEC. The main molecular mechanisms of YTHDC2 focused on catalytic activity, helicase activity, snRNA binding, spliceosome and mRNA surveillance. Additionally, YTHDC2 was notably correlated with tumour immune infiltration. Moreover, YTHDC2 had a high diagnostic value for seven cancer types and a prognostic value for brain lower grade glioma (LGG), rectum adenocarcinoma (READ) and skin cutaneous melanoma (SKCM). Collectively, YTHDC2 plays a significant role in epigenetic modification and immune infiltration and maybe a potential biomarker for diagnosis and prognosis in certain cancers.

中文翻译：

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YTH结构域2在泛癌表观遗传修饰和免疫浸润中的作用

YTH 结构域含有 2 (YTHDC2) 是最大的 N6-甲基腺苷 (m ⁶A) YTH 蛋白家族的结合蛋白和唯一含有 ATP 依赖性 RNA 解旋酶活性的成员。为进一步分析其在表观遗传修饰中的生物学作用，我们利用一系列数据库和生物信息学从基因表达、基因改变、蛋白质-蛋白质相互作用（PPI）网络、免疫浸润、诊断价值和预后价值等方面对YTHDC2进行了全面探索。工具。我们发现带有错义突变的YTHDC2可导致子宫体子宫内膜癌（UCEC）的不同预后，其不同的甲基化水平可导致肾上腺皮质癌（ACC）、宫颈鳞状细胞癌和宫颈管腺癌（CESC）的完全不同的预后、肺鳞状细胞癌 (LUSC) 和 UCEC。YTHDC2的主要分子机制集中在催化活性上，解旋酶活性、snRNA 结合、剪接体和 mRNA 监测。此外，YTHDC2 与肿瘤免疫浸润显着相关。此外，YTHDC2 对七种癌症类型具有很高的诊断价值，对脑低级别胶质瘤 (LGG)、直肠腺癌 (READ) 和皮肤皮肤黑色素瘤 (SKCM) 具有预后价值。总的来说，YTHDC2 在表观遗传修饰和免疫浸润中发挥着重要作用，可能是某些癌症诊断和预后的潜在生物标志物。