当前位置: X-MOL 学术Thorax › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A telerehabilitation programme in post-discharge COVID-19 patients (TERECO): a randomised controlled trial
Thorax ( IF 10 ) Pub Date : 2022-07-01 , DOI: 10.1136/thoraxjnl-2021-217382
Jian'an Li 1, 2 , Wenguang Xia 3 , Chao Zhan 4 , Shouguo Liu 1, 2 , Zhifei Yin 1 , Jiayue Wang 1, 2 , Yufei Chong 3 , Chanjuan Zheng 3 , Xiaoming Fang 4 , Wei Cheng 4 , Jan D Reinhardt 5, 6, 7, 8
Affiliation  

Objectives To investigate superiority of a telerehabilitation programme for COVID-19 (TERECO) over no rehabilitation with regard to exercise capacity, lower limb muscle strength (LMS), pulmonary function, health-related quality of life (HRQOL) and dyspnoea. Design Parallel-group randomised controlled trial with 1:1 block randomisation. Setting Three major hospitals from Jiangsu and Hubei provinces, China. Participants 120 formerly hospitalised COVID-19 survivors with remaining dyspnoea complaints were randomised with 61 allocated to control and 59 to TERECO. Intervention Unsupervised home-based 6-week exercise programme comprising breathing control and thoracic expansion, aerobic exercise and LMS exercise, delivered via smartphone, and remotely monitored with heart rate telemetry. Outcomes Primary outcome was 6 min walking distance (6MWD) in metres. Secondary outcomes were squat time in seconds; pulmonary function assessed by spirometry; HRQOL measured with Short Form Health Survey-12 (SF-12) and mMRC-dyspnoea. Outcomes were assessed at 6 weeks (post-treatment) and 28 weeks (follow-up). Results Adjusted between-group difference in change in 6MWD was 65.45 m (95% CI 43.8 to 87.1; p<0.001) at post-treatment and 68.62 m (95% CI 46.39 to 90.85; p<0.001) at follow-up. Treatment effects for LMS were 20.12 s (95% CI 12.34 to 27.9; p<0.001) post-treatment and 22.23 s (95% CI 14.24 to 30.21; p<0.001) at follow-up. No group differences were found for lung function except post-treatment maximum voluntary ventilation. Increase in SF-12 physical component was greater in the TERECO group with treatment effects estimated as 3.79 (95% CI 1.24 to 6.35; p=0.004) at post-treatment and 2.69 (95% CI 0.06 to 5.32; p=0.045) at follow-up. Conclusions This trial demonstrated superiority of TERECO over no rehabilitation for 6MWD, LMS, and physical HRQOL. Trial registration number ChiCTR2000031834. Anonymised patient-level data on which the analysis, results and conclusions reported in this paper are based are available as Dryad dataset. Reinhardt, Jan D. (2021), Telerehabilitation program for COVID-19 survivors (TERECO) - randomized controlled trial, Dryad, Dataset,
更新日期:2022-06-15
down
wechat
bug