当前位置:
X-MOL 学术
›
Chem. Soc. Rev.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Recent developments of metal-based compounds against fungal pathogens
Chemical Society Reviews ( IF 46.2 ) Pub Date : 2021-07-27 , DOI: 10.1039/d0cs00945h Yan Lin 1 , Harley Betts 1 , Sarah Keller 1 , Kevin Cariou 1 , Gilles Gasser 1
Chemical Society Reviews ( IF 46.2 ) Pub Date : 2021-07-27 , DOI: 10.1039/d0cs00945h Yan Lin 1 , Harley Betts 1 , Sarah Keller 1 , Kevin Cariou 1 , Gilles Gasser 1
Affiliation
This review provides insight into the rapidly expanding field of metal-based antifungal agents. In recent decades, the antibacterial resistance crisis has caused reflection on many aspects of public health where weaknesses in our medicinal arsenal may potentially be present – including in the treatment of fungal infections, particularly in the immunocompromised and those with underlying health conditions where mortality rates can exceed 50%. Combination of organic moieties with known antifungal properties and metal ions can lead to increased bioavailability, uptake and efficacy. Development of such organometallic drugs may alleviate pressure on existing antifungal medications. Prodigious antimicrobial moieties such as azoles, Schiff bases, thiosemicarbazones and others reported herein lend themselves easily to the coordination of a host of metal ions, which can vastly improve the biocidal activity of the parent ligand, thereby extending the library of antifungal drugs available to medical professionals for treatment of an increasing incidence of fungal infections. Overall, this review shows the impressive but somewhat unexploited potential of metal-based compounds to treat fungal infections.
中文翻译:
金属基化合物抗真菌病原体的新进展
这篇综述提供了对快速扩展的金属基抗真菌剂领域的见解。近几十年来,抗菌素耐药性危机已经引起了公共卫生的许多方面的思考,这些方面可能存在我们的药物库中可能存在的弱点——包括真菌感染的治疗,特别是在免疫功能低下的人和有潜在健康问题的人,死亡率可能会降低超过 50%。具有已知抗真菌特性的有机部分与金属离子的组合可提高生物利用度、吸收和功效。开发此类有机金属药物可能会减轻现有抗真菌药物的压力。惊人的抗菌部分,如唑类、席夫碱、缩氨基硫脲和本文报道的其他化合物很容易与大量金属离子配位,这可以大大提高母体配体的杀生物活性,从而扩展医疗专业人员可用的抗真菌药物库,用于治疗日益增加的真菌感染. 总体而言,这篇综述显示了基于金属的化合物治疗真菌感染的令人印象深刻但有些未开发的潜力。
更新日期:2021-07-27
中文翻译:
金属基化合物抗真菌病原体的新进展
这篇综述提供了对快速扩展的金属基抗真菌剂领域的见解。近几十年来,抗菌素耐药性危机已经引起了公共卫生的许多方面的思考,这些方面可能存在我们的药物库中可能存在的弱点——包括真菌感染的治疗,特别是在免疫功能低下的人和有潜在健康问题的人,死亡率可能会降低超过 50%。具有已知抗真菌特性的有机部分与金属离子的组合可提高生物利用度、吸收和功效。开发此类有机金属药物可能会减轻现有抗真菌药物的压力。惊人的抗菌部分,如唑类、席夫碱、缩氨基硫脲和本文报道的其他化合物很容易与大量金属离子配位,这可以大大提高母体配体的杀生物活性,从而扩展医疗专业人员可用的抗真菌药物库,用于治疗日益增加的真菌感染. 总体而言,这篇综述显示了基于金属的化合物治疗真菌感染的令人印象深刻但有些未开发的潜力。