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Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson’s disease
Cell Proliferation ( IF 8.5 ) Pub Date : 2021-07-26 , DOI: 10.1111/cpr.13094
Qing Li 1, 2 , Chenye Shen 1 , Zhaolin Liu 1 , Yuanyuan Ma 1 , Jinghui Wang 1 , Hongtian Dong 1 , Xiaoshuang Zhang 1 , Zishan Wang 1 , Mei Yu 1 , Lei Ci 2 , Ruilin Sun 2 , Ruling Shen 3, 4 , Jian Fei 3, 4, 5 , Fang Huang 1
Affiliation  

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive and selective degeneration of dopaminergic neurons. Microglial activation and neuroinflammation are associated with the pathogenesis of PD. However, the relationship between microglial activation and PD pathology remains to be explored.

中文翻译:

小胶质细胞的部分消耗和再增殖在帕金森病急性 MPTP 小鼠模型中具有不同的影响

帕金森病 (PD) 是一种常见的神经退行性疾病,其特征是多巴胺能神经元的进行性和选择性退化。小胶质细胞激活和神经炎症与 PD 的发病机制有关。然而,小胶质细胞激活与 PD 病理之间的关系仍有待探索。
更新日期:2021-08-09
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