We report herein a strategy to afford a multicomponent catalytic enantioselective synthesis of β-substituted isoxazolidin-5-ones via a KMC process promoted by a suited cupreine used as bifunctional organocatalyst. The hydroxamic acid component, with a sterically hindered amide moiety, proved to be key for the successful formation and transformation of the obtained original N-amide isoxazolidin-5-ones.

中文翻译：

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多组分催化对映选择性合成异恶唑烷-5-酮

我们在此报告了一种策略，该策略通过由用作双功能有机催化剂的合适铜碱促进的 KMC 过程提供 β-取代的异恶唑烷-5-酮的多组分催化对映选择性合成。具有空间位阻酰胺部分的异羟肟酸组分被证明是获得的原始N-酰胺异恶唑烷-5-酮成功形成和转化的关键。