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Prevalence of SARS-CoV-2 RNA on inanimate surfaces: a systematic review and meta-analysis
European Journal of Epidemiology ( IF 13.6 ) Pub Date : 2021-07-27 , DOI: 10.1007/s10654-021-00784-y
Simone Belluco 1 , Marzia Mancin 1 , Filippo Marzoli 1 , Alessio Bortolami 2 , Eva Mazzetto 2 , Alessandra Pezzuto 1 , Michela Favretti 1 , Calogero Terregino 2 , Francesco Bonfante 2 , Roberto Piro 1
Affiliation  

Coronavirus disease (COVID-19) is a respiratory disease affecting many people and able to be transmitted through direct and perhaps indirect contact. Direct contact transmission, mediated by aerosols or droplets, is widely demonstrated, whereas indirect transmission is only supported by collateral evidence such as virus persistence on inanimate surfaces and data from other similar viruses. The present systematic review aims to estimate SARS-CoV-2 prevalence on inanimate surfaces, identifying risk levels according to surface characteristics. Data were obtained from studies in published papers collected from two databases (PubMed and Embase) with the last search on 1 September 2020. Included studies had to be papers in English, had to deal with coronavirus and had to consider inanimate surfaces in real settings. Studies were coded according to our assessment of the risk that the investigated surfaces could be contaminated by SARS-CoV-2. A meta-analysis and a metaregression were carried out to quantify virus RNA prevalence and to identify important factors driving differences among studies. Thirty-nine out of forty retrieved paper reported studies carried out in healthcare settings on the prevalence of virus RNA, five studies carry out also analyses through cell culture and six tested the viability of isolated viruses. Overall prevalences of SARS-CoV-2 RNA on high-, medium- and low-risk surfaces were 0.22 (CI95 [0.152–0.296]), 0.04 (CI95 [0.007–0.090]), and 0.00 (CI95 [0.00–0.019]), respectively. The duration surfaces were exposed to virus sources (patients) was the main factor explaining differences in prevalence.



中文翻译:

SARS-CoV-2 RNA 在无生命表面的流行:系统回顾和荟萃分析

冠状病毒病 (COVID-19) 是一种影响许多人的呼吸道疾病,能够通过直接和间接接触传播。由气溶胶或飞沫介导的直接接触传播已得到广泛证明,而间接传播仅得到附带证据的支持,例如病毒在无生命表面上的持久性以及来自其他类似病毒的数据。本系统评价旨在估计 SARS-CoV-2 在无生命表面的流行率,根据表面特征确定风险水平。数据是从两个数据库(PubMed 和 Embase)收集的已发表论文的研究中获得的,最后一次搜索是在 2020 年 9 月 1 日。纳入的研究必须是英文论文,必须处理冠状病毒,并且必须考虑真实环境中的无生命表面。根据我们对调查的表面可能被 SARS-CoV-2 污染的风险的评估对研究进行了编码。进行了荟萃分析和元回归以量化病毒 RNA 流行率并确定导致研究差异的重要因素。在检索到的 40 篇论文中,有 39 篇报告了在医疗机构中对病毒 RNA 流行率进行的研究,五项研究还通过细胞培养进行了分析,六项研究测试了分离病毒的生存能力。SARS-CoV-2 RNA 在高、中、低风险表面的总体流行率为 0.22 (CI 在检索到的 40 篇论文中,有 39 篇报告了在医疗机构中对病毒 RNA 流行率进行的研究,五项研究还通过细胞培养进行了分析,六项研究测试了分离病毒的生存能力。SARS-CoV-2 RNA 在高、中、低风险表面的总体流行率为 0.22 (CI 在检索到的 40 篇论文中,有 39 篇报告了在医疗机构中对病毒 RNA 流行率进行的研究,五项研究还通过细胞培养进行了分析,六项研究测试了分离病毒的生存能力。SARS-CoV-2 RNA 在高、中、低风险表面的总体流行率为 0.22 (CI95 [0.152–0.296])、0.04 (CI 95 [0.007–0.090]) 和 0.00 (CI 95 [0.00–0.019]) 。表面暴露于病毒源(患者)的持续时间是解释流行率差异的主要因素。

更新日期:2021-07-27
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