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A Novel Case of Concurrent T-cell and Early T-cell Precursor Lymphoblastic Lymphoma in an Adolescent Female.
Journal of Pediatric Hematology/Oncology ( IF 1.2 ) Pub Date : 2021-07-23 , DOI: 10.1097/mph.0000000000002257
Charles Treinen 1 , Mohammad H Abu-Arja 2 , Samir B Kahwash 3 , Hemalatha G Rangarajan 1, 4 , Faye Willen 1 , Anthony N Audino 1, 4
Affiliation  

In the context of an evolving understanding of early T-cell precursor (ETP) lymphoma and leukemia, we present a case of concurrent T-cell lymphoblastic lymphoma and ETP lymphoma in an adolescent female. To our knowledge, this represents the first reported case of both lymphoblastic lymphoma and ETP lymphoma as distinct and conjoined components of the same neoplasm. As an exception to current literature, our patient had a strictly lymphomatous ETP component with no leukemic manifestation. Her ETP component remained viable following induction, supporting ETP resistance to chemotherapy. The patient remains in remission 4 years postallogeneic matched sibling donor bone marrow transplant.

中文翻译:

青少年女性并发 T 细胞和早期 T 细胞前体淋巴细胞淋巴瘤的新病例。

在对早期 T 细胞前体 (ETP) 淋巴瘤和白血病的理解不断发展的背景下,我们提出了一个青少年女性并发 T 细胞淋巴母细胞淋巴瘤和 ETP 淋巴瘤的病例。据我们所知,这代表了首次报道的淋巴母细胞淋巴瘤和 ETP 淋巴瘤作为同一肿瘤的不同和联合成分的病例。作为当前文献的一个例外,我们的患者有严格的淋巴瘤 ETP 成分,没有白血病表现。她的 ETP 成分在诱导后仍然存活,支持 ETP 对化疗的耐药性。患者在异基因匹配的同胞供体骨髓移植后 4 年仍处于缓解期。
更新日期:2021-07-23
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