Long-acting injectable antipsychotics (LAIs) increase drug compliance and offer a reliable treatment option with stable pharmacokinetics. The aim of our study is to examine the rate and predictors of LAIs' prescription at discharge in inpatients with schizophrenia and other psychotic disorders. This retrospective study included 400 inpatients. Sociodemographic and clinical characteristics of the patients, the treatments applied in the past and prescribed at discharge were obtained from the hospitalization files. We compared these characteristics of those who were given LAI treatment at discharge to the patients who were given oral treatments. Thirty-nine percent of the patients were prescribed a LAI at discharge. Duration of illness was longer, and number of previous hospitalizations was higher in the LAI group. Nonadherence to the antipsychotics before the hospitalization, the previous history of LAI use, lack of insight at the admission and no previous antidepressant use were found as independent contributors to LAI prescription as the treatment of discharge in logistic regression analysis. Our study showed that LAIs are used at a high rate in our clinic; however, they are still initiated at a later stage, mostly in chronic patients with a lack of insight and compliance at admission.

中文翻译：

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精神分裂症和其他精神病患者出院时长效注射用抗精神病药处方的预测因素。

长效注射用抗精神病药 (LAI) 可提高药物依从性，并提供具有稳定药代动力学的可靠治疗选择。我们研究的目的是检查精神分裂症和其他精神障碍住院患者出院时 LAI 处方的比率和预测因素。这项回顾性研究包括 400 名住院患者。从住院档案中获得患者的社会人口学和临床特征、过去应用的治疗和出院时的处方。我们将出院时接受 LAI 治疗的患者与接受口服治疗的患者的这些特征进行了比较。39% 的患者在出院时接受了 LAI。LAI 组的病程更长，既往住院次数更多。在逻辑回归分析中，住院前不依从抗精神病药、既往 LAI 使用史、入院时缺乏洞察力和既往未使用抗抑郁药作为 LAI 处方作为出院治疗的独立贡献者。我们的研究表明，LAI 在我们的诊所中使用率很高；然而，它们仍处于后期阶段，主要是在入院时缺乏洞察力和依从性的慢性患者。