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Ultrasound-assisted synthesis of pyrimidines and their fused derivatives: A review
Ultrasonics Sonochemistry ( IF 8.4 ) Pub Date : 2021-07-27 , DOI: 10.1016/j.ultsonch.2021.105683
Mateus Mittersteiner 1 , Fellipe F S Farias 1 , Helio G Bonacorso 1 , Marcos A P Martins 1 , Nilo Zanatta 1
Affiliation  

The pyrimidine scaffold is present in many bioactive drugs; therefore, efficient synthetic routes that provide shorter reaction times, higher yields, and site-selective reactions are constantly being sought. Ultrasound (US) irradiation has emerged as an alternative energy source in the synthesis of these heterocyclic scaffolds, and over the last ten years there has been a significant increase in the number of publications mentioning US in either the construction or derivatization of the pyrimidine core. This review presents a detailed summary (with 140 references) of the effects of US (synergic or not) on the construction and derivatization of the pyrimidine core through classical reactions (e.g., multicomponent, cyclocondensation, cycloaddition, and alkylation reactions). The main points that were taken into consideration are as follows: chemo- and regioselectivity issues, and the results of conventional heating methods compared to US and mechanistic insights that are also presented and discussed for key reactions.



中文翻译:

嘧啶及其稠合衍生物的超声辅助合成:综述

嘧啶支架存在于许多生物活性药物中。因此,一直在寻求可提供更短反应时间、更高产率和位点选择性反应的有效合成路线。超声 (US) 辐射已成为合成这些杂环支架的替代能源,并且在过去十年中,在嘧啶核的构建或衍生化中提及 US 的出版物数量显着增加。本综述通过经典反应(例如,多组分反应、环缩合反应、环加成反应和烷基化反应)对 US(协同与否)对嘧啶核的构建和衍生化的影响进行了详细总结(包含 140 篇参考文献)。主要考虑如下:

更新日期:2021-09-23
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