AbstractIntroductionThe impact of cardiovascular risk burden on brain pathologies remains unclear. We aimed to examine the association of the Framingham General Cardiovascular Risk Score (FGCRS) with dementia risk, and brain pathologies.MethodsWithin the Rush Memory and Aging Project, 1588 dementia‐free participants were assessed on FGCRS at baseline and followed up to 21 years. During the follow‐up, 621 participants died and underwent autopsies.ResultsThe multi‐adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of FGCRS were 1.03 (1.00–1.07) for dementia and 1.04 (1.01–1.07) for Alzheimer's disease (AD) dementia. Further, a higher FGCRS was associated with higher gross chronic cerebral infarctions (odds ratio [OR] 1.08, 95% CI 1.02–1.14), cerebral atherosclerosis (OR 1.10, 95% CI 1.03–1.17), and global AD pathology (OR 1.06, 95% CI 1.01–1.12).ConclusionsA higher FGCRS is associated with an increased risk of dementia and AD dementia. Both vascular and AD pathologies in the brain may underlie this association.

中文翻译：

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心血管风险负担与痴呆和脑部病变风险的关联：一项基于人群的队列研究

摘要介绍心血管风险负担对大脑病理的影响仍不清楚。我们的目的是研究弗雷明汉一般心血管风险评分 (FGCRS) 与痴呆风险和脑部病理的关联。方法在 Rush Memory and Aging Project 中，1588 名无痴呆症参与者接受了 FGCRS 基线评估，并随访长达 21 年。在随访期间，621 名参与者死亡并接受了尸检。结果FGCRS 的痴呆症多重调整风险比 (HR)（95% 置信区间 [CI]）为 1.03 (1.00–1.07)，阿尔茨海默病 (AD) 痴呆为 1.04 (1.01–1.07)。此外，较高的 FGCRS 与较高的慢性脑梗塞（比值比 [OR] 1.08，95% CI 1.02–1.14）、脑动脉粥样硬化（OR 1.10，95% CI 1.03–1.17）和整体 AD 病理学（OR 1.06）相关。 ，95% CI 1.01–1.12）。结论FGCRS 较高与痴呆和 AD 痴呆的风险增加相关。大脑中的血管和 AD 病理可能是这种关联的基础。