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Thalamus mediates neocortical Down state transition via GABAB-receptor-targeting interneurons
Neuron ( IF 16.2 ) Pub Date : 2021-07-26 , DOI: 10.1016/j.neuron.2021.06.030
Y Audrey Hay 1 , Nicolas Deperrois 1 , Tanja Fuchsberger 1 , Thomas Matthew Quarrell 1 , Anna-Lucia Koerling 1 , Ole Paulsen 1
Affiliation  

Slow-wave sleep is characterized by near-synchronous alternation of active Up states and quiescent Down states in the neocortex. Although the cortex itself can maintain these oscillations, the full expression of Up-Down states requires intact thalamocortical circuits. Sensory thalamic input can drive the cortex into an Up state. Here we show that midline thalamic neurons terminate Up states synchronously across cortical areas. Combining local field potential, single-unit, and patch-clamp recordings in conjunction with optogenetic stimulation and silencing in mice in vivo, we report that thalamic input mediates Down transition via activation of layer 1 neurogliaform inhibitory neurons acting on GABAB receptors. These results strengthen the evidence that thalamocortical interactions are essential for the full expression of slow-wave sleep, show that Down transition is an active process mediated by cortical GABAB receptors, and demonstrate that thalamus synchronizes Down transitions across cortical areas during natural slow-wave sleep.



中文翻译:

丘脑通过 GABAB 受体靶向中间神经元介导新皮质向下状态转变

慢波睡眠的特点是新皮质中活跃的向上状态和静止的向下状态几乎同步交替。虽然皮层本身可以维持这些振荡,但上下状态的完整表达需要完整的丘脑皮质回路。感觉丘脑输入可以驱动皮层进入向上状态。在这里,我们展示了中线丘脑神经元跨皮质区域同步终止向上状态。将局部场电位、单单元和膜片钳记录与体内小鼠的光遗传学刺激和沉默相结​​合,我们报告说丘脑输入通过激活作用于 GABA B的第 1 层神经胶质细胞抑制神经元介导向下转换受体。这些结果加强了丘脑皮质相互作用对于慢波睡眠的充分表达必不可少的证据,表明向下转换是由皮质 GABA B受体介导的活跃过程,并证明在自然慢波睡眠期间,丘脑同步跨皮质区域的向下转换睡觉。

更新日期:2021-09-01
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