The steady increase in global cancer burden has fuelled the development of several modes of treatment for the disease. In the presence of an actionable mutation, targeted therapies offer a method to selectively attack cancer cells, increasing overall efficacy and reducing harmful side effects. However, different drug molecules are in different stages of development, with new molecules obtaining approvals from regulatory agencies each year. To augment clinical impact, it is important that this information reaches clinicians, patients and researchers swiftly and in a structured, well-annotated manner. To this end, we have developed Mutation-Specific Therapies Resource and Database in Cancer (MUSTARD), a database that is designed to be a centralized resource with diverse information such as cancer subtype, associated mutations, therapy offered and its effect observed, along with links to external resources for a more comprehensive annotation. In its current version, MUSTARD comprises over 2105 unique entries, including associations between 418 unique drug therapies, 189 cancer subtypes and 167 genes curated and annotated from over 862 different publications. To the best of our knowledge, it is the only resource that offers comprehensive information on mutation-specific, gene fusions and overexpressed gene-targeted therapies for cancer. Database URL: http://clingen.igib.res.in/mustard/

中文翻译：

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MUSTARD——癌症突变特异性疗法的综合资源

全球癌症负担的稳步增加推动了该疾病几种治疗模式的发展。在存在可操作突变的情况下，靶向治疗提供了一种选择性攻击癌细胞的方法，提高整体疗效并减少有害副作用。然而，不同的药物分子处于不同的开发阶段，每年都有新分子获得监管机构的批准。为了增加临床影响，重要的是这些信息以结构化、注释良好的方式迅速传递给临床医生、患者和研究人员。为此，我们开发了癌症突变特异性疗法资源和数据库 (MUSTARD)，该数据库旨在成为具有多种信息的集中资源，例如癌症亚型、相关突变、提供的治疗方法和观察到的效果，以及指向外部资源的链接以进行更全面的注释。在其当前版本中，MUSTARD 包含超过 2105 个独特的条目，包括 418 种独特的药物疗法、189 种癌症亚型以及来自 862 多种不同出版物的 167 个基因之间的关联。据我们所知，它是唯一提供有关癌症突变特异性、基因融合和过表达基因靶向疗法的全面信息的资源。数据库网址：http://clingen.igib.res.in/mustard/ 189 种癌症亚型和 167 个基因从超过 862 份不同的出版物中整理和注释。据我们所知，它是唯一提供有关癌症突变特异性、基因融合和过表达基因靶向疗法的全面信息的资源。数据库网址：http://clingen.igib.res.in/mustard/ 189 种癌症亚型和 167 个基因从超过 862 份不同的出版物中整理和注释。据我们所知，它是唯一提供有关癌症突变特异性、基因融合和过表达基因靶向疗法的全面信息的资源。数据库网址：http://clingen.igib.res.in/mustard/