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“Core” RxLR effectors in phytopathogenic oomycetes: A promising way to breeding for durable resistance in plants?
Virulence ( IF 5.2 ) Pub Date : 2021-07-25 , DOI: 10.1080/21505594.2021.1948277
Jane Chepsergon 1 , Thabiso E Motaung 1 , Lucy Novungayo Moleleki 1
Affiliation  

ABSTRACT

Phytopathogenic oomycetes are known to successfully infect their hosts due to their ability to secrete effector proteins. Of interest to many researchers are effectors with the N-terminal RxLR motif (Arginine-any amino acid-Leucine-Arginine). Owing to advances in genome sequencing, we can now comprehend the high level of diversity among oomycete effectors, and similarly, their conservation within and among species referred to here as “core” RxLR effectors (CREs). Currently, there is a considerable number of CREs that have been identified in oomycetes. Functional characterization of these CREs propose their virulence role with the potential of targeting central cellular processes that are conserved across diverse plant species. We reason that effectors that are highly conserved and recognized by the host, could be harnessed in engineering plants for durable as well as broad-spectrum resistance.



中文翻译:

植物病原性卵菌中的“核心”RxLR 效应器:一种有希望的育种方法以实现植物的持久抗性?

摘要

已知植物病原性卵菌能够成功感染宿主,因为它们具有分泌效应蛋白的能力。许多研究人员感兴趣的是具有 N 端 RxLR 基序(精氨酸-任何氨基酸-亮氨酸-精氨酸)的效应子。由于基因组测序的进步,我们现在可以理解卵菌效应子之间的高度多样性,以及类似地,它们在此处称为“核心” R xLR e的物种内部和物种之间的保守性效应器(CRE)。目前,已经在卵菌中发现了大量的 CRE。这些 CRE 的功能表征提出了它们的毒力作用,具有靶向在不同植物物种中保守的中央细胞过程的潜力。我们推断,高度保守和被宿主识别的效应子可以在工程植物中被利用,以获得持久的和广谱的抗性。

更新日期:2021-07-26
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