Abstract

Objective

The presence of intracoronary thrombus is associated with adverse events in patients with ST-segment elevation myocardial infarction (STEMI). PRECISE-DAPT score is used to detect the bleeding risk in STEMI patients who are on dual antiplatelet therapy. Recently, the PRECISE-DAPT score was shown to be related to cardiovascular events. We aimed to investigate the association of PRECISE-DAPT score with thrombus burden in patients with STEMI.

Methods

A retrospective analysis with 204 STEMI patients undergoing primary percutaneous coronary intervention was conducted in this study. Thrombus burden grade and PRECISE-DAPT score were calculated for each subject. Patients were divided into two groups as high thrombus burden (HTB) (grade 4, 5) and low thrombus burden (LTB) (grade 1, 2 and 3) based on thrombus burden grade. The PRECISE-DAPT scores were compared between thrombus burden groups.

Results

The mean age in HTB (N = 136) was 63.7 (11.3), and 64.7% were male. HTB had a higher PRECISE-DAPT score than LTB (p < .0001). PRECISE-DAPT score, baseline troponin I levels, ejection fraction, and pain to balloon time were independent predictors of HTB.

Conclusions

PRECISE-DAPT score was an independent predictor of HTB in patients with STEMI.

中文翻译：

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ST 段抬高型心肌梗死患者 PRECISE-DAPT 评分与血栓负荷的关系

摘要

客观的

冠状动脉内血栓的存在与 ST 段抬高型心肌梗死 (STEMI) 患者的不良事件相关。PRECISE-DAPT 评分用于检测接受双重抗血小板治疗的 STEMI 患者的出血风险。最近，PRECISE-DAPT 评分被证明与心血管事件有关。我们的目的是研究 PRECISE-DAPT 评分与 STEMI 患者血栓负荷的关系。

方法

本研究对 204 名接受初次经皮冠状动脉介入治疗的 STEMI 患者进行了回顾性分析。计算每个受试者的血栓负荷等级和 PRECISE-DAPT 评分。根据血栓负荷等级将患者分为高血栓负荷（HTB）（4、5级）和低血栓负荷（LTB）（1、2和3级）两组。比较血栓负荷组之间的 PRECISE-DAPT 评分。

结果

HTB ( N = 136)的平均年龄 为 63.7 (11.3)，其中 64.7% 为男性。HTB 的 PRECISE-DAPT 得分高于 LTB ( p  < .0001)。PRECISE-DAPT 评分、基线肌钙蛋白 I 水平、射血分数和球囊疼痛时间是 HTB 的独立预测因素。

结论

PRECISE-DAPT 评分是 STEMI 患者 HTB 的独立预测因子。