Abstract

Microbial biofilms are difficult to control due to the limited accessibility that antimicrobial drugs and chemicals have to the entrapped inner cells. The extracellular matrix, binds water, contributes to altered cell physiology within biofilms and act as a barrier for most antiproliferative molecules. Thus, new strategies need to be developed to overcome biofilm vitality. In this review, based on 223 documents, the advantages, recommendations, and limitations of using bacteriophages as ‘biofilm predators’ are presented. The plausibility of using phages (bacteriophages and mycoviruses) to control biofilms grown in different environments is also discussed. The topics covered here include recent historical experiences in biofilm control/eradication using phages in medicine, dentistry, veterinary, and food industries, the pros and cons of their use, and the development of microbial resistance/immunity to such viruses.

摘要

由于抗菌药物和化学物质对被包裹的内细胞的可及性有限，微生物生物膜难以控制。细胞外基质与水结合，有助于改变生物膜内的细胞生理学，并作为大多数抗增殖分子的屏障。因此，需要开发新的策略来克服生物膜的活力。在这篇综述中，基于 223 份文件，介绍了使用噬菌体作为“生物膜捕食者”的优点、建议和局限性。还讨论了使用噬菌体（噬菌体和真菌病毒）控制在不同环境中生长的生物膜的合理性。此处涵盖的主题包括在医学、牙科、兽医和食品工业中使用噬菌体控制/根除生物膜的近期历史经验，其使用的利弊，