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Typically asymptomatic but with robust antibody formation: Children’s unique humoral immune response to SARS-CoV-2
medRxiv - Pediatrics Pub Date : 2021-07-22 , DOI: 10.1101/2021.07.20.21260863
Hanna Renk , Alex Dulovic , Matthias Becker , Dorit Fabricius , Maria Zernickel , Daniel Junker , Alina Seidel , Rüdiger Groß , Alexander Hilger , Sebastian Bode , Linus Fritsch , Pauline Frieh , Anneke Haddad , Tessa Görne , Jonathan Remppis , Tina Ganzemueller , Andrea Dietz , Daniela Huzly , Hartmut Hengel , Klaus Kaier , Susanne Weber , Eva-Maria Jacobsen , Philipp D. Kaiser , Bjoern Traenkle , Ulrich Rothbauer , Maximilian Stich , Burkhard Tönshoff , Georg F. Hoffmann , Barbara Müller , Carolin Ludwig , Bernd Jahrsdörfer , Hubert Schrezenmeier , Andreas Peter , Sebastian Hörber , Thomas Iftner , Jan Münch , Thomas Stamminger , Hans-Jürgen Groß , Martin Wolkewitz , Corinna Engel , Marta Rizzi , Philipp Henneke , Axel R. Franz , Klaus-Michael Debatin , Nicole Schneiderhan-Marra , Ales Janda , Roland Elling

Background Long-term persistence of antibodies against SARS-CoV-2, particularly the SARS-CoV-2 Spike Trimer, determines individual protection against infection and potentially viral spread. The quality of children’s natural humoral immune response following SARS-CoV-2 infection is yet incompletely understood but crucial to guide pediatric SARS-CoV-2 vaccination programs.

中文翻译:

通常无症状但具有强大的抗体形成:儿童对 SARS-CoV-2 的独特体液免疫反应

背景针对 SARS-CoV-2 的抗体(尤其是 SARS-CoV-2 Spike Trimer)的长期持续存在决定了个体对感染和潜在病毒传播的保护。儿童感染 SARS-CoV-2 后自然体液免疫反应的质量尚不完全清楚,但对指导儿童 SARS-CoV-2 疫苗接种计划至关重要。
更新日期:2021-07-26
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