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Aortic Valve Calcification Score in Patients with Arterial Hypertension Environmentally Exposed to Tobacco Smoke
Cardiovascular Toxicology ( IF 3.2 ) Pub Date : 2021-07-26 , DOI: 10.1007/s12012-021-09677-8
Paweł Gać 1, 2 , Adrian Martuszewski 1 , Patrycja Paluszkiewicz 1 , Małgorzata Poręba 3 , Grzegorz Mazur 4 , Rafał Poręba 4
Affiliation  

The objective of our study was to determine the relationship between exposure to environmental tobacco smoke (ETS) and the value of the aortic valve calcification score (AVCS) in people suffering from arterial hypertension (AH). 107 non-smokers with AH (mean age 67.16 ± 8.48 years) were qualified for the study. The degree of exposure to ETS was assessed using the Second-hand Smoke Exposure Scale (SHSES) questionnaire. Study group was divided depending on ETS exposure: A—no exposure, B—low, C—medium and D—high. AVCS was measured based on the aortic valve plane multiplanar reconstruction from the non-contrast phase of the cardiac computed tomography. The Agatston algorithm was used, in which calcifications were considered changes with a density exceeding 130 HU. The mean AVCS value in the study group of patients was 213.59 ± 304.86. The AVCS was significantly lower in subgroup A than in subgroups C and D. In subgroup A, the lack of aortic valve calcification (AVCS = 0) was observed significantly more frequently than in subgroups C and D. There was a positive correlation between the number of SHSES points and the AVCS value (r = 0.37, p < 0.05). Based on the ROC curve, the SHSES value was determined as the optimal cut-off point for the prediction of AVCS = 0, amounting to 3 points. The accuracy of SHSES < 3 as the predictor of AVCS = 0 was set at 62.18%. Hypertensive patients have an unfavourable relationship between the amount of exposure to ETS, determined on the SHSES scale, and the AVCS value.



中文翻译:

环境暴露于烟草烟雾的动脉高血压患者的主动脉瓣钙化评分

我们研究的目的是确定暴露于环境烟草烟雾 (ETS) 与动脉高血压 (AH) 患者的主动脉瓣钙化评分 (AVCS) 值之间的关系。107 名患有 AH 的非吸烟者(平均年龄 67.16 ± 8.48 岁)符合研究条件。使用二手烟暴露量表 (SHSES) 问卷评估暴露于 ETS 的程度。研究组根据 ETS 暴露情况分为:A-无暴露,B-低,C-中,D-高。AVCS 是根据心脏计算机断层扫描的非对比阶段的主动脉瓣平面多平面重建来测量的。使用了 Agatston 算法,其中钙化被认为是密度超过 130 HU 的变化。研究组患者的平均 AVCS 值为 213.59 ± 304.86。r  = 0.37,p  < 0.05)。根据 ROC 曲线,确定 SHSES 值作为预测 AVCS = 0 的最佳分界点,共 3 个点。SHSES < 3 作为 AVCS = 0 的预测因子的准确度设定为 62.18%。高血压患者在 ETS 暴露量(根据 SHSES 量表确定)与 AVCS 值之间存在不利关系。

更新日期:2021-07-26
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