Zearalenone (ZEN) is a mycotoxin that contaminates crops worldwide and whose toxic adverse effects are well documented. This study aims to evaluate the protective effect of gallic acid (GA) against biochemical, oxidative, inflammatory, and pathological changes in ZEN treated rats’ hepatorenal system. Wistar rats (n = 50; 150 ± 30 g) were randomly grouped into five cohorts (= 10) specifically: Control (rat chow); ZEN alone (100 µg/kg; per os), GA alone (40 mg/kg; per os), ZEN + GA1 (100 µg/kg + 20 mg/kg per os) and ZEN + GA2 (100 µg/kg + 40 mg/kg per os) and the study was for 28 successive days. Upon terminal sacrifice, biomarkers of hepatorenal function and oxidative stress were analyzed. An assessment of cytokine levels (IL-1β, IL-10) and histopathology of the liver and kidneys was also performed. Relative to the control, serum levels of urea, creatinine, and hepatic transaminases increased significantly (p < 0.05) in the ZEN alone group and reduced in groups co-treated with GA. ZEN treatment further resulted in decreases in the rat’s antioxidant status. The increase in the reactive oxygen and nitrogen species (RONS) and lipid peroxidation (LPO) levels caused by ZEN exposure was reduced by GA in a dose-dependent manner (p < 0.05). Furthermore, ZEN-mediated increase in nitric oxide (NO), xanthine oxidase (XO), IL-1β, and myeloperoxidase (MPO) levels and suppression of IL-10 levels were reversed in the liver and kidney of GA co-treated rats. The extent of ZEN-mediated hepatorenal lesions was reduced in rats co-treated with GA. Our findings suggest that GA effectively abated biochemical, oxido-inflammatory and histological alteration caused by ZEN exposure, limiting ZEN toxicity and cellular damage in rats’ hepatic and renal tissues.

玉米赤霉烯酮 (ZEN) 是一种真菌毒素，可污染世界范围内的作物，其毒性不利影响已得到充分证明。本研究旨在评估没食子酸 (GA) 对 ZEN 治疗大鼠肝肾系统的生化、氧化、炎症和病理变化的保护作用。Wistar 大鼠（n = 50；150 ± 30 g）被随机分为五个队列（= 10）：对照（大鼠饲料）；ZEN 单独（100 µg/kg；每口）、GA 单独（40 mg/kg；每口）、ZEN + GA1（100 µg/kg + 20 mg/kg每口）和 ZEN + GA2（100 µg/kg + 40毫克/千克口服) 并且研究是连续 28 天。在终末处死后，分析肝肾功能和氧化应激的生物标志物。还对细胞因子水平（IL-1β、IL-10）和肝脏和肾脏的组织病理学进行了评估。相对于对照组，单独使用 ZEN 组的尿素、肌酐和肝转氨酶的血清水平显着增加（p < 0.05），而在联合 GA 治疗组中则降低。ZEN 治疗进一步导致大鼠的抗氧化状态下降。GA 以剂量依赖性方式降低了由 ZEN 暴露引起的活性氧和氮物质 (RONS) 和脂质过氧化 (LPO) 水平的增加(p < 0.05). 此外，在 GA 联合治疗的大鼠的肝脏和肾脏中，ZEN 介导的一氧化氮 (NO)、黄嘌呤氧化酶 (XO)、IL-1β 和髓过氧化物酶 (MPO) 水平的增加以及 IL-10 水平的抑制被逆转。在与 GA 共同治疗的大鼠中，ZEN 介导的肝肾病变程度降低。我们的研究结果表明，GA 有效地减轻了由 ZEN 暴露引起的生化、氧化炎症和组织学改变，限制了 ZEN 毒性和大鼠肝肾组织的细胞损伤。