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T cell exhaustion—a memory locked behind scars
Nature Immunology ( IF 30.5 ) Pub Date : 2021-07-26 , DOI: 10.1038/s41590-021-00977-3
Amir Yousif 1 , Hazem E Ghoneim 1, 2
Affiliation  

Following clearance of chronic infections, virus-specific CD8+ T cells recover a subset of memory-related transcriptome features. Yet their unique open chromatin landscape largely reflects an exhausted or dysfunctional state, limiting their protective memory potential.

中文翻译:

T 细胞耗竭——锁在疤痕后面的记忆

在清除慢性感染后,病毒特异性 CD8+ T 细胞会恢复一部分与记忆相关的转录组特征。然而,它们独特的开放染色质景观在很大程度上反映了一种疲惫或功能失调的状态,限制了它们的保护性记忆潜力。
更新日期:2021-07-26
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