Hypoxia within the plateau has a negative effect on skeletal muscle and may play a role in the development of sarcopenia in humans. Tibetans having lived in the Qinghai-Tibet Plateau for thousands of years, are a high-risk group for sarcopenia; however, they have a distinctive suite of genetic traits that enable them to tolerate environmental hypoxia and are genetically significantly different from Han Chinese and other lowland populations. Sarcopenia has been consistently found to be associated with single-nucleotide polymorphisms, but few studies have investigated the role of single-nucleotide polymorphisms in a range of muscle phenotypes and sarcopenia in Tibetan peoples.

中文翻译：

---

藏族人肌肉减少症易感性与FTO、ACVR2B、IRS1多态性的关系

高原内的缺氧对骨骼肌有负面影响，并且可能在人类肌肉减少症的发展中发挥作用。藏族人在青藏高原生活了数千年，是肌肉减少症的高危人群；然而，它们具有一套独特的遗传特征，使它们能够耐受环境缺氧，并且在遗传上与汉族和其他低地种群有显着差异。一直发现肌肉减少症与单核苷酸多态性有关，但很少有研究调查单核苷酸多态性在藏族人的一系列肌肉表型和肌肉减少症中的作用。