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Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy ( IF 3.3 ) Pub Date : 2021-07-24 , DOI: 10.2147/dmso.s315362
Shidong Tan 1 , Guangyao Zang 1 , Ying Wang 1 , Zhen Sun 1 , Yalan Li 1 , Cheng Lu 2 , Zhongqun Wang 1
Affiliation  

Abstract: Angiogenesis, as a process occurring under the regulation of a variety of factors, is one of the important ways of vascular development. It coexists in a variety of pathological and physiological processes. Now a large number of studies have proved that tumor growth, metastasis, and various vascular complications of diabetes are closely related to angiogenesis, and an increasing number of studies have shown that there are many common factors between the two. But angiogenesis is the opposite of the two: it is enhanced in tumors and suppressed in diabetes. Therefore, this review discusses the causes of the phenomenon from the expression of various factors affecting angiogenesis in these two diseases and their effects on angiogenesis in the relevant microenvironment, as well as the application status of these factors or cells as therapeutic targets in the treatment of these two diseases.

Keywords: diabetes mellitus, tumor, angiogenesis, differences, tumor microenvironment, hypoxia


中文翻译:

肿瘤与糖尿病血管生成因子的差异

摘要:血管生成作为在多种因素调控下发生的过程,是血管发育的重要途径之一。它共存于多种病理生理过程中。现在大量研究证明糖尿病的肿瘤生长、转移和各种血管并发症与血管生成密切相关,越来越多的研究表明两者之间存在许多共同因素。但血管生成是两者的对立面:它在肿瘤中增强而在糖尿病中被抑制。因此,本综述从影响血管生成的各种因素在这两种疾病中的表达及其对相关微环境中血管生成的影响,探讨了这一现象的成因,

关键词:糖尿病,肿瘤,血管生成,差异,肿瘤微环境,缺氧
更新日期:2021-07-24
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