The management of diabetes mellitus mandates measurement of blood glucose. Saliva offers an alternative to blood sampling, but measurement of the salivary glucose concentration is difficult, and the blood-to-saliva glucose time lag is uncertain. We aimed to determine the serum–saliva glucose time lag in the saliva of healthy dogs. The combined duct of the mandibular and sublingual salivary glands of 6 dogs was cannulated to collect saliva and prevent glucose degradation by oral bacteria. Following a 0.25 g/kg IV bolus of dextrose, paired serum–saliva samples were collected at baseline and in twelve 5-min blocks over 60 min. Serum and salivary glucose levels were analyzed with a linear mixed model for repeated measures with a compound symmetry error structure. Mean (±SD) saliva production was 10.3 ± 2.9 µL/kg/min, and the area under the curve (AUC_glucose)_saliva/serum ratio was 0.006, which highlights the magnitude of the large difference in glucose concentration between the 2 compartments. The serum–saliva glucose time lag was 30–40 min.

糖尿病的管理要求测量血糖。唾液提供了血液采样的替代方法，但唾液葡萄糖浓度的测量很困难，并且血液到唾液葡萄糖的时间滞后是不确定的。我们旨在确定健康犬唾液中的血清-唾液葡萄糖时间滞后。对6只犬的下颌和舌下唾液腺联合导管进行插管以收集唾液并防止口腔细菌对葡萄糖的降解。在静脉推注 0.25 g/kg 葡萄糖后，在基线和 60 分钟内以 12 个 5 分钟的块收集配对的血清-唾液样本。使用线性混合模型分析血清和唾液葡萄糖水平，用于具有复合对称误差结构的重复测量。平均 (±SD) 唾液产量为 10.3 ± 2.9 µL/kg/min，曲线下面积 (AUC_葡萄糖）_{唾液/血清}比为 0.006，这突出了 2 个隔室之间葡萄糖浓度的巨大差异。血清-唾液葡萄糖时滞为 30-40 分钟。