Post-translational modifications (PTMs) on histone proteins are known as epigenetic marks that demarcate the status of chromatin. These modifications are ‘read' by specific reader proteins, which in turn recruit additional factors to modulate chromatin accessibility and the activity of the underlying DNA. Accumulating evidence suggests that these modifications are not restricted solely to histones, many non-histone proteins may function in a similar way through mimicking the histones. In this commentary, we briefly discuss a systematic study of the discovery of histone H3 N-terminal mimicry proteins (H3TMs), and their implications in chromatin regulation and drug discoveries.

中文翻译：

---

组蛋白模仿物：更多故事要读

组蛋白上的翻译后修饰 (PTM) 被称为表观遗传标记，用于划分染色质的状态。这些修饰被特定的阅读蛋白“读取”，这些蛋白反过来又会招募额外的因素来调节染色质的可及性和潜在 DNA 的活性。越来越多的证据表明，这些修饰不仅限于组蛋白，许多非组蛋白可能通过模仿组蛋白以类似的方式发挥作用。在这篇评论中，我们简要讨论了对组蛋白 H3 N 端模拟蛋白 (H3TM) 的发现及其在染色质调控和药物发现中的影响的系统研究。