Purpose

To explore the prevalence of sleep disturbances and their effects on quality of life in adults with pituitary tumor or meningioma.

Methods

This prospective study included 33 and 44 patients with pituitary tumor and meningioma, respectively. All participants completed a series of valid questionnaires for assessing sleep and quality of life; all participants wore 3-day actigraph prior to related treatment. The actigraph-derived sleep parameters included total sleep time, sleep onset latency, wake after sleep onset, sleep efficiency, and dichotomy index (I < O) value.

Results

The prevalence of insomnia, excessive daytime sleepiness, and poor sleep quality was 46.8%, 6.5%, and 81.8%, respectively. The differences in these sleep parameters between patients with pituitary tumor and those with meningioma were nonsignificant. Only 27 participants completed the actigraphic assessments. The mean I < O value was 95.99%, and nearly 60% participants exhibited circadian rhythm disruption. Sleep quality was the only sleep variable independently correlated with preoperative quality of life, even after adjustments for confounders (B = 0.80, p = 0.02).

Conclusions

Insomnia, poor sleep quality, and disrupted circadian rhythm are highly prevalent in adults with untreated pituitary tumor or meningioma. Sleep quality independently correlated with quality of life. We indirectly confirmed that tumor location may not be a possible cause of sleep changes.

中文翻译：

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未经治疗的垂体瘤和脑膜瘤成人睡眠障碍的患病率及其对生活质量的影响

目的

探讨睡眠障碍的患病率及其对垂体瘤或脑膜瘤成人生活质量的影响。

方法

这项前瞻性研究分别包括 33 名和 44 名垂体瘤和脑膜瘤患者。所有参与者都完成了一系列评估睡眠和生活质量的有效问卷；所有参与者在相关治疗前都佩戴了 3 天的活动记录仪。活动记录仪衍生的睡眠参数包括总睡眠时间、入睡潜伏期、入睡后醒来、睡眠效率和二分法指数 (I < O) 值。

结果

失眠、白天过度嗜睡和睡眠质量差的患病率分别为46.8%、6.5%和81.8%。垂体瘤患者和脑膜瘤患者在这些睡眠参数方面的差异不显着。只有 27 名参与者完成了动作评估。平均 I < O 值为 95.99%，近 60% 的参与者表现出昼夜节律紊乱。睡眠质量是唯一与术前生活质量独立相关的睡眠变量，即使在调整了混杂因素后也是如此（B = 0.80，p  = 0.02）。

结论

失眠、睡眠质量差和昼夜节律紊乱在未经治疗的垂体瘤或脑膜瘤的成年人中非常普遍。睡眠质量与生活质量独立相关。我们间接证实肿瘤位置可能不是睡眠变化的可能原因。