The choroid plexus (ChP), an epithelial bilayer containing a network of mesenchymal, immune, and neuronal cells, forms the blood–cerebrospinal fluid (CSF) barrier (BCSFB). While best recognized for secreting CSF, the ChP is also a hotbed of immune cell activity and can provide circulating peripheral immune cells with passage into the central nervous system (CNS). Here, we review recent studies on ChP immune cells, with a focus on the ontogeny, development, and behaviors of ChP macrophages, the principal resident immune cells of the ChP. We highlight the implications of immune cells for ChP barrier function, CSF cytokines and volume regulation, and their contribution to neurodevelopmental disorders, with possible age-specific features to be elucidated in the future.

脉络丛 (ChP) 是一种上皮双层，包含间充质细胞、免疫细胞和神经元细胞网络，形成血脑脊液 (CSF) 屏障 (BCSFB)。虽然以分泌 CSF 最为公认，但 ChP 也是免疫细胞活动的温床，可以为循环的外周免疫细胞提供进入中枢神经系统 (CNS) 的通道。在这里，我们回顾了最近对 ChP 免疫细胞的研究，重点是 ChP 巨噬细胞（ChP 的主要常驻免疫细胞）的个体发育、发育和行为。我们强调免疫细胞对 ChP 屏障功能、脑脊液细胞因子和体积调节的影响，以及它们对神经发育障碍的贡献，未来可能会阐明年龄特异性特征。