Oxidative biotransformations find a prominent role in the fine chemical industry and the valorization of renewable feedstocks. Implementation of oxygen-dependent reactions faces some challenges across scales and at different levels of development. First, the fruitful development of enzyme candidates and identification of reaction possibilities is not in consonance with the implementation in process engineering. Second, reaction engineering faces a complex interplay of reaction kinetic, oxygen transfer and process stability. Third, given the advances in synergic fields such as molecular biology, chemistry, material sciences, and (micro)process engineering, an interdisciplinary assembly from a consistent discipline around heterogeneous biocatalyst engineering would be of strategic value. We show advances in design of active and robust immobilized enzyme catalysts to be applied in (continuous) intensified processes. A framework based on the joint design of a catalyst and reactor will be discussed for the design and optimization of the catalysts and biotransformations involved.

氧化生物转化在精细化工和可再生原料的增值中发挥着重要作用。氧依赖反应的实施面临着跨规模和不同发展水平的一些挑战。首先，候选酶的富有成效的开发和反应可能性的鉴定与工艺工程的实施不一致。其次，反应工程面临反应动力学、氧转移和过程稳定性的复杂相互作用。第三，鉴于分子生物学、化学、材料科学和（微）过程工程等协同领域的进展，围绕异质生物催化剂工程的一致学科的跨学科组合将具有战略价值。我们展示了在（连续）强化过程中​​应用的活性和稳健的固定化酶催化剂的设计进展。将讨论基于催化剂和反应器联合设计的框架，以设计和优化所涉及的催化剂和生物转化。