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Drug Sensitivity Profile of Fungi Isolated from Onychomycosis Patients and Evaluation of Squalene Epoxidase Mutation in One Terbinafine-Resistant Trichophyton mentagrophytes Species
Microbial Drug Resistance ( IF 2.6 ) Pub Date : 2021-12-06 , DOI: 10.1089/mdr.2020.0572 Alireza Firooz 1 , Maryam Daneshpazhooh 2 , Ensieh Lotfali 3 , Mahshid Sharzad Kavkani 4 , Zeinab Ghasemi 5 , Ali Khamesipoor 1 , Mansour Nassiri Kashani 1 , Akram Miramin Mohammadi 1 , Seyed Ebrahim Skandari 1 , Saman Ahmad Nasrollahi 1 , Azam Fattahi 1
Microbial Drug Resistance ( IF 2.6 ) Pub Date : 2021-12-06 , DOI: 10.1089/mdr.2020.0572 Alireza Firooz 1 , Maryam Daneshpazhooh 2 , Ensieh Lotfali 3 , Mahshid Sharzad Kavkani 4 , Zeinab Ghasemi 5 , Ali Khamesipoor 1 , Mansour Nassiri Kashani 1 , Akram Miramin Mohammadi 1 , Seyed Ebrahim Skandari 1 , Saman Ahmad Nasrollahi 1 , Azam Fattahi 1
Affiliation
Background: The resistance to treatment of onychomycosis is increasingly reported. The present study aimed to assess the antifungal activity of itraconazole, terbinafine, luliconazole, and efinaconazole against dermatophytes, molds, and also yeast isolated from patients with onychomycosis. Furthermore, the mechanism of resistance to terbinafine in resistant Trichophyton mentagrophytes species was evaluated using the squalene epoxidase (SQLE) gene sequence.
中文翻译：
从甲癣患者中分离出的真菌的药物敏感性特征和一种抗特比萘芬须癣毛癣菌物种中角鲨烯环氧酶突变的评价
背景：越来越多地报道了对甲癣治疗的耐药性。本研究旨在评估伊曲康唑、特比萘芬、卢立康唑和艾氟康唑对皮肤癣菌、霉菌以及从甲癣患者中分离出的酵母菌的抗真菌活性。此外，使用角鲨烯环氧酶（ SQLE）基因序列评估了抗性须癣毛癣菌对特比萘芬的抗性机制
更新日期：2021-12-08
中文翻译：
从甲癣患者中分离出的真菌的药物敏感性特征和一种抗特比萘芬须癣毛癣菌物种中角鲨烯环氧酶突变的评价
背景：越来越多地报道了对甲癣治疗的耐药性。本研究旨在评估伊曲康唑、特比萘芬、卢立康唑和艾氟康唑对皮肤癣菌、霉菌以及从甲癣患者中分离出的酵母菌的抗真菌活性。此外，使用角鲨烯环氧酶（ SQLE）基因序列评估了抗性须癣毛癣菌对特比萘芬的抗性机制
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