Early detection of hepatocellular carcinoma (HCC) while in its early stages is critical for reducing HCC mortality in high-risk patients. However, highly sensitive and specific surveillance biomarkers for early-stage HCC detection are still lacking. In recent years, great efforts have been made to research tumor-derived molecular features that are detectable in circulation, such as circulating tumor deoxyribonucleic acid and circulating tumor ribonucleic acid, in order to explore their potential as non-invasive biomarker candidates in many tumor types. In this review, we summarize current studies on these new approaches and their application in early HCC detection.

早期发现肝细胞癌 (HCC) 对降低高危患者的 HCC 死亡率至关重要。然而，仍然缺乏用于早期 HCC 检测的高度敏感和特异的监测生物标志物。近年来，人们努力研究循环中可检测的肿瘤衍生分子特征，例如循环肿瘤脱氧核糖核酸和循环肿瘤核糖核酸，以探索它们作为多种肿瘤类型中非侵入性生物标志物候选物的潜力。 . 在这篇综述中，我们总结了目前关于这些新方法及其在早期 HCC 检测中的应用的研究。