This article tells the story of hormesis from its conceptual and experimental origins, its dismissal by the scientific and medical communities in the first half of the 20th century, and its rediscovery over the past several decades to be a fundamental evolutionary adaptive strategy. The upregulation of hormetic adaptive mechanisms has the capacity to decelerate the onset and reduce the severity of a broad spectrum of common age-related health, behavioral, and performance decrements and debilitating diseases, thereby significantly enhancing the human health span. Incorporation of hormetic-based lifestyle options within the human population would have profoundly positive impacts on the public health, significantly reducing health care costs.

中文翻译：

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Hormesis：改变依赖剂量反应的学科

本文从概念和实验起源、20 世纪上半叶被科学界和医学界摒弃，以及在过去几十年中重新发现它成为一种基本的进化适应性策略来讲述兴奋剂的故事。兴奋性适应性机制的上调能够减缓各种常见的与年龄相关的健康、行为和表现下降以及使人衰弱的疾病的发病并降低其严重程度，从而显着提高人类健康水平。在人群中纳入基于兴奋剂的生活方式选择将对公众健康产生深远的积极影响，从而显着降低医疗保健成本。