Endometrial cancer is a common gynaecological cancer, is typically early stage and treated with surgery. For patients where surgery is difficult or dangerous, definitive radiation therapy is the next best option. This study included a single institution case series (step 1) and a systematic review of the literature (step 2). In step 1, all endometrial cancer cases that were treated with definitive image-guided brachytherapy at a single institution from 2008 to 2020 were retrospectively analysed. In step 2, a systematic review of Medline (PubMed) from 1975 to 2020 was carried out using the key words around endometrial cancer and brachytherapy, followed by a narrative synthesis. In total, in step 1, 31 cases were included in this study, stages I–IV, with 96.7% receiving external beam radiation. All patients received three fractions of 7.5 Gy or five fractions of 6 Gy high dose rate brachytherapy, with a median EQD2 of 75.55 (40–84.3). The 2-year Kaplan-Meier (KM) local control was 83.1% and the 2-year KM overall survival was 77.4%. There was no late toxicity ≥grade 3. In step 2, 19 articles were included in the final analysis, with between six and 280 patients. The local control ranged from 70 to 100%, with low toxicity. Definitive radiation therapy with image-guided brachytherapy seems to have good local control with low toxicity for patients who are poor surgical candidates.

子宫内膜癌是一种常见的妇科癌症，通常处于早期阶段并通过手术治疗。对于手术困难或危险的患者，确定性放射治疗是次优选择。这项研究包括一个单一的机构案例系列（步骤 1）和对文献的系统回顾（步骤 2）。在步骤 1 中，回顾性分析了 2008 年至 2020 年在单一机构接受明确影像引导近距离放射治疗的所有子宫内膜癌病例。在步骤 2 中，使用围绕子宫内膜癌和近距离放射治疗的关键词对 1975 年至 2020 年的 Medline (PubMed) 进行系统回顾，然后进行叙述性综合。在第 1 步中，本研究共包括 31 例病例，即 I-IV 期，其中 96.7% 接受外部光束辐射。所有患者都接受了 7 的三个分数。5 Gy 或 6 Gy 高剂量率近距离放射治疗的五个部分，中位 EQD2 为 75.55 (40–84.3)。2 年 Kaplan-Meier (KM) 局部控制率为 83.1%，2 年 KM 总生存率为 77.4%。没有≥3级的晚期毒性。在第2步中，19篇文章被纳入最终分析，6至280名患者。局部控制范围为70%～100%，毒性低。对于不适合手术的患者，使用图像引导近距离放射治疗的确定性放射治疗似乎具有良好的局部控制和低毒性。有 6 到 280 名患者。局部控制范围为70%～100%，毒性低。对于不适合手术的患者，使用图像引导近距离放射治疗的确定性放射治疗似乎具有良好的局部控制和低毒性。有 6 到 280 名患者。局部控制范围为70%～100%，毒性低。对于不适合手术的患者，使用图像引导近距离放射治疗的确定性放射治疗似乎具有良好的局部控制和低毒性。