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Therapeutic potential evaluation of green synthesized silver nanoparticles derived from olive (Olea europaea L.) leaf extracts against breast cancer cells
Journal of Nanophotonics ( IF 1.5 ) Pub Date : 2021-07-01 , DOI: 10.1117/1.jnp.15.036003
Hassna Alhajri 1 , Seham Alterary 1 , Bahauddeen M. Alrfaei 2 , Wedad S. Al-Qahtani 3
Affiliation  

The improvement of a green synthetic approach that focuses on the use of olive leaf extract took place to produce silver nanoparticles (AgNPs). This synthesis is known for its cost efficiency and ecological safety, with the potential to be applied in massive AgNP production. The cytotoxic, anticancer, and antioxidant activities of olive leaf extracts with AgNPs were examined on breast cancer cell lines following preparation of olive leaf extracts utilizing a method of extraction at a temperature of (0°C/8 h). Total flavonoids and phenolics for olive leaves with extraction through ethanolic and water solvents were 43.52 mg / ml and 132.9 and 64.73 mg / ml and 293.32, respectively. UV-Vis spectroscopy that has the sizes of absorption peaks from 420 to 440 mm was used to describe the synthesized AgNPs nanoparticles. Scanning electron microscopy verified these particles, specifying that they are characterized by the spherical shape of and being 100 nm on average. AgNPs’s antioxidant activity was significant. Additionally, a cytotoxic activity dependent on concentration was shown by green synthesized AgNPs. This is the initial study that established olive leaf extracts biological activity at 0°C/8 h temperature utilizing ethanol and water solvents followed by biosynthesized AgNPs from the extracts and their therapeutic potential.

中文翻译:

来自橄榄(Olea europaea L.)叶提取物的绿色合成银纳米粒子对乳腺癌细胞的治疗潜力评估

专注于使用橄榄叶提取物的绿色合成方法的改进用于生产银纳米粒子 (AgNPs)。这种合成以其成本效益和生态安全性而闻名,有可能应用于大规模的 AgNP 生产。在使用温度为 (0°C/8 小时) 的提取方法制备橄榄叶提取物后,在乳腺癌细胞系上检测了含有 AgNPs 的橄榄叶提取物的细胞毒性、抗癌和抗氧化活性。通过乙醇和水溶剂提取的橄榄叶的总黄酮类化合物和酚类物质分别为 43.52 毫克/毫升和 132.9 和 64.73 毫克/毫升和 293.32。吸收峰尺寸从 420 到 440 mm 的紫外-可见光谱用于描述合成的 AgNPs 纳米粒子。扫描电子显微镜验证了这些粒子,指出它们的特征是球形,平均为 100 nm。AgNPs 的抗氧化活性是显着的。此外,绿色合成的 AgNPs 显示出依赖于浓度的细胞毒活性。这是利用乙醇和水溶剂在 0°C/8 小时温度下建立橄榄叶提取物生物活性的初步研究,然后从提取物中生物合成 AgNPs 及其治疗潜力。
更新日期:2021-07-24
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