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Valveless pumping behavior of the simulated embryonic heart tube as a function of contractile patterns and myocardial stiffness.
Biomechanics and Modeling in Mechanobiology ( IF 3.5 ) Pub Date : 2021-07-23 , DOI: 10.1007/s10237-021-01489-7
Alireza Sharifi 1 , Alex Gendernalik 2 , Deborah Garrity 3 , David Bark 1, 2, 4
Affiliation  

During development, the heart begins pumping as a valveless multilayered tube capable of driving blood flow throughout the embryonic vasculature. The mechanical properties and how they interface with pumping function are not well-defined at this stage. Here, we evaluate pumping patterns using a fluid-structure interaction computational model, combined with experimental data and an energetic analysis to investigate myocardial mechanical properties. Through this work, we propose that a myocardium modeled as a Neo-Hookean material with a material constant on the order of 10 kPa is necessary for the heart tube to function with an optimal pressure and cardiac output.

中文翻译:

模拟胚胎心管的无阀泵送行为与收缩模式和心肌僵硬度的关系。

在发育过程中,心脏开始作为无瓣的多层管泵血,能够驱动血液在整个胚胎脉管系统中流动。在这个阶段,机械性能以及它们如何与泵送功能相互作用并没有明确定义。在这里,我们使用流固耦合计算模型评估泵送模式,并结合实验数据和能量分析来研究心肌力学性能。通过这项工作,我们建议将心肌建模为具有 10 kPa 量级材料常数的 Neo-Hookean 材料,这样心脏管才能以最佳压力和心输出量发挥作用。
更新日期:2021-07-23
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