Abstract

Regulatory T (Treg) cells that express the lineage-defining transcription factor Foxp3 play a pivotal role in establishing and maintaining immune and tissue homeostasis. Foxp3 serves as a highly connected “hub”, interacting with numerous genomic sites and partner proteins, in the molecular network that orchestrates multiple facets of Treg cell differentiation and function. Treg cells are distributed throughout the body from lymphoid tissues to most non-lymphoid tissues, where they exert anti-inflammatory and protective functions appropriate for the tissue and immune environment. They are thus capable of adapting to diverse and changing environments by dynamically integrating extrinsic cues with the intrinsic molecular network. In this review, we discuss recent advances in our understanding of the cell-intrinsic and -extrinsic mechanisms underlying the adaptability of Treg cells and we propose a crucial role for the Foxp3-centered molecular network, which operates in a multimodal and adaptive manner in response to environmental signals.

中文翻译：

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调节性 T 细胞和 Foxp3 的适应性

摘要

表达谱系定义转录因子 Foxp3 的调节性 T (Treg) 细胞在建立和维持免疫和组织稳态方面发挥着关键作用。Foxp3 作为一个高度连接的“枢纽”，在协调 Treg 细胞分化和功能的多个方面的分子网络中与众多基因组位点和伙伴蛋白相互作用。Treg细胞分布在全身，从淋巴组织到大多数非淋巴组织，它们发挥适合组织和免疫环境的抗炎和保护功能。因此，它们能够通过将外在线索与内在分子网络动态整合来适应多样化和不断变化的环境。在本次审查中，