For correct and reliable experimental in vivo assessment of antistress effect of various bioactive substances, appropriate biomodels reproducing stress and organism response to stress in laboratory animals should be chosen. We chose treadmill test for simulating exhaustive physical load and forced immobilization accompanied by disorders of physiological and psychological condition. Verification of the models used indicates their wide applicability for testing certain biological manifestations under reproduced stress exposure.

中文翻译：

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力竭训练或强制固定对 Wistar 雄性大鼠生理状况及主要代谢和应激标志物的影响

为了对各种生物活性物质的抗应激作用进行正确和可靠的体内实验评估，应选择合适的生物模型来复制实验动物的应激和生物体对应激的反应。我们选择跑步机测试来模拟体力消耗和强迫固定伴随的生理和心理状况障碍。对所用模型的验证表明它们可广泛适用于在重复的压力暴露下测试某些生物学表现。