We examined 74 patients with acute decompensation of alcoholic liver cirrhosis: 34 (45.9%) with bacterial infection (group 1) and 40 (54.1%) without bacterial infection (group 2). The degree and index of acute-on-chronic liver failure (ACLF) were determined using an on-line CLIF-C ACLF Calculator and the levels of cytokeratin-18 fragments, TNFα, IL-1β, IL-4, IL-6, and IL-8. In group 1, AST, cytokeratin-18, TNFα, IL-1β, IL-6, degree and score of ACLF were significantly higher than in group 2. ACLF developed in 18 (52.9%) patients in group 1 and in 11 (27.5%) (p<0.05) patients in group 2. Within 1 month, 10 (29.4%) patients of group 1 and 2 (5%) patients of group 2 died (p<0.05). Patients with bacterial infection showed a more severe course of alcoholic liver cirrhosis and ACLF than those without bacterial infection.

我们检查了 74 名酒精性肝硬化急性失代偿患者：34 名（45.9%）有细菌感染（第 1 组），40 名（54.1%）没有细菌感染（第 2 组）。使用在线 CLIF-C ACLF 计算器和细胞角蛋白 18 片段、TNFα、IL-1β、IL-4、IL-6、和 IL-8。在第 1 组中，AST、细胞角蛋白-18、TNFα、IL-1β、IL-6、ACLF 程度和评分显着高于第 2 组。第 1 组有 18 名（52.9%）患者和 11 名（27.5 %) ( p <0.05) 组 2 患者。1 个月内，组 1 10 (29.4%) 例患者和组 2 2 (5%) 患者死亡 ( p<0.05)。与没有细菌感染的患者相比，细菌感染患者的酒精性肝硬化和 ACLF 病程更为严重。