当前位置: X-MOL 学术Chem › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Supramolecular hydrogelation via host-guest anion recognition: Lamellar hydrogel materials for the release of cationic cargo
Chem ( IF 23.5 ) Pub Date : 2021-07-23 , DOI: 10.1016/j.chempr.2021.06.024
Zoran Kokan 1 , Miroslava Dušková-Smrčková 2 , Vladimír Šindelář 1
Affiliation  

Hydrogelation triggered by host-guest anion recognition is difficult to achieve due to the challenging anion recognition in water and de novo gelator design. Herein, we report such a hydrogel system, based on bambus[6]uril anion receptor, BU. Albeit not a gelator per se, BU formed hydrogels selectively in the presence of iodides or perchlorates. Anion recognition by BU governed the hydrogelation, indicated by the NMR, ATR-IR, and single-crystal X-ray. Gelation mechanism and lamellar nature of the network structure were elucidated by SAXS, cryoSEM, and holotomography methods. Rheological characterization revealed the hydrogels were stable and relatively strong. In physiological saline solutions, the hydrogels released cationic cargo by cation metathesis, leading to a gel-to-gel transformation. Choline derivatives, as model drugs, exhibited slow release from the hydrogels. Our simple hydrogel system may inspire the design of smart materials based on host-guest anion recognition, where the release or sequestration of specific charged species are desirable.



中文翻译:

通过主客体阴离子识别进行超分子水凝胶化:用于释放阳离子货物的层状水凝胶材料

由于水中阴离子识别和从头凝胶剂设计具有挑战性,因此由主客体阴离子识别触发的水凝胶很难实现。在这里,我们报告了这样一种水凝胶系统,基于竹[6] uril 阴离子受体,BU。尽管BU本身不是凝胶剂,但在碘化物或高氯酸盐的存在下选择性地形成水凝胶。BU负离子识别控制水凝胶,由 NMR、ATR-IR 和单晶 X 射线表明。通过 SAXS、cryoSEM 和全息成像方法阐明了网络结构的凝胶机制和层状性质。流变学表征显示水凝胶稳定且相对坚固。在生理盐水溶液中,水凝胶通过阳离子复分解作用释放阳离子货物,导致凝胶到凝胶的转化。胆碱衍生物作为模型药物,从水凝胶中缓慢释放。我们简单的水凝胶系统可能会启发基于主客体阴离子识别的智能材料的设计,其中特定带电物质的释放或隔离是可取的。

更新日期:2021-09-09
down
wechat
bug