Tomato seeds contain steroidal saponins called lycoperosides. However, it currently remains unclear whether lycoperosides exert anti-inflammatory or anti-allergic effects. Therefore, we herein investigated the effects of tomato seed extract (TSE) and lycoperoside H (LH) in Interleukin (IL)-33 transgenic mice. TSE (500 mg/kg) or LH (10 mg/kg) was orally administered once a day for 101 days and then evaluated mouse behavior, skin symptoms, and blood and skin inflammatory cytokines. TSE slightly suppressed scratching behavior, while TSE and LH both increased locomotive activity. LH also significantly suppressed inflammation scores in the limbs, and TSE and LH reduced transepidermal water loss. Epidermal hyperplasia and the accumulation of eosinophils and mast cells were decreased by TSE and LH. Skin Th2/Th1 cytokine ratio and serum IgE concentrations were significantly reduced by TSE and LH. The present results suggest that the oral administration of LH derived from tomato seeds effectively ameliorates the symptoms of atopic dermatitis.

中文翻译：

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番茄种子中的甾体生物碱皂苷番茄红素 H 可改善 IL-33 转基因小鼠的特应性皮炎样症状

番茄种子含有称为番茄红素的甾体皂苷。然而，目前尚不清楚番茄红素是否具有抗炎或抗过敏作用。因此，我们在此研究了番茄种子提取物 (TSE) 和番茄红素 H (LH) 对白细胞介素 (IL)-33 转基因小鼠的影响。每天口服一次 TSE (500 mg/kg) 或 LH (10 mg/kg)，持续 101 天，然后评估小鼠行为、皮肤症状以及血液和皮肤炎症细胞因子。TSE 略微抑制抓挠行为，而 TSE 和 LH 都增加了机车活动。LH 还显着抑制了四肢的炎症评分，TSE 和 LH 减少了经皮水分流失。TSE 和 LH 减少了表皮增生和嗜酸性粒细胞和肥大细胞的积累。TSE 和 LH 可显着降低皮肤 Th2/Th1 细胞因子比和血清 IgE 浓度。目前的结果表明，口服来自番茄种子的 LH 可有效改善特应性皮炎的症状。