As the molecular mechanisms of biological aging become better understood, there is growing interest in identifying interventions that target those mechanisms to promote extended health and longevity. The budding yeast Saccharomyces cerevisiae has served as a premier model organism for identifying genetic and molecular factors that modulate cellular aging and is a powerful system in which to evaluate candidate longevity interventions. Here we screened a collection of natural products and natural product mixtures for effects on the growth rate, mTOR-mediated growth inhibition, and replicative lifespan. No mTOR inhibitory activity was detected, but several of the treatments affected growth rate and lifespan. The strongest lifespan shortening effects were observed for green tea extract and berberine. The most robust lifespan extension was detected from an extract of Pterocarpus marsupium and another mixture containing Pterocarpus marsupium extract. These findings illustrate the utility of the yeast system for longevity intervention discovery and identify Pterocarpus marsupium extract as a potentially fruitful longevity intervention for testing in higher eukaryotes.

随着生物衰老的分子机制得到更好的理解，人们越来越关注确定针对这些机制以促进延长健康和长寿的干预措施。发芽酵母酿酒酵母已作为识别调节细胞衰老的遗传和分子因素的主要模式生物，并且是评估候选长寿干预措施的强大系统。在这里，我们筛选了一系列天然产物和天然产物混合物对生长速率、mTOR 介导的生长抑制和复制寿命的影响。未检测到 mTOR 抑制活性，但几种治疗影响了生长速度和寿命。绿茶提取物和小檗碱的寿命缩短效果最强。从紫檀提取物和另一种含有紫檀的混合物中检测到最有效的寿命延长提炼。这些发现说明了酵母系统在发现长寿干预方面的实用性，并将有袋紫檀提取物确定为一种可能富有成效的长寿干预措施，用于在高等真核生物中进行测试。